지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 670 - 675 (6page)
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초록· 키워드
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Purpose Cisplatin-associated arterial and venous thromboembolic events (TEEs) are becoming anincreasing concern. In patients with small-cell lung cancer (SCLC) who are treated usingcisplatin-based chemotherapy, we assume that the overall risk of TEEs is high. However,cisplatin-associated vascular toxicity in patients with SCLC has been overlooked to date.
The aim of this study was to determine the incidence of TEEs in patients with SCLC and toanalyze the predictors for TEE occurrence.
Materials and MethodsWe retrospectively analyzed 277 patients who received chemotherapy for SCLC between2006 and 2012. As the influence of chemotherapy on TEE occurrence developed after itsinitiation, a time-dependent Cox regression analysis was used to estimate the significantpredictors for TEE.
ResultsAmong the 277 patients, 30 patients (11%) developed a TEE. The 3-month, 6-month, and1-year cumulative incidences of TEEs were 5.0%, 9.1%, and 10.2%, respectively. Of 30 totalTEEs, 22 (73%) occurred between the time of initiation and 4 weeks after the last dose ofplatinum-based chemotherapy. Approximately 218 patients (79%) received cisplatin-basedchemotherapy. In multivariate analysis, cisplatin-based chemotherapy was an independentrisk factor for TEE occurrence (hazard ratio [HR], 4.36; p=0.05). Variables including smokingstatus (common HR, 2.14; p=0.01) and comorbidity index (common HR, 1.60; p=0.05) alsoshowed significant association with TEE occurrence.
ConclusionThe 1-year cumulative incidence of TEE is 10.2% in Asian patients with SCLC. Cisplatinbasedchemotherapy in SCLC might be a strong predictor for the risk of TEE.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Blom JW / 2005 / Malignancies, prothrombotic mutations, and the risk of venous thrombosis / JAMA 293 : 715 ~ 722
Chew HK / 2006 / Incidence of venous thromboembolism and its effect on survival among patients with common cancers / Arch Intern Med 166 : 458 ~ 464
Chew HK / 2008 / The incidence of venous thromboembolism among patients with primary lung cancer / J Thromb Haemost 6 : 601 ~ 608
Czaykowski PM / 1998 / High risk of vascular events in patients with urothelial transitional cell carcinoma treated with cisplatin based chemotherapy / J Urol 160 (6Pt 1) :
Heit JA / 2000 / Risk factors for deep vein thrombosis and pulmonary embolism : a population-based case-control study / Arch Intern Med 160 : 809 ~ 815
Chew HK / 2006 / Incidence of venous thromboembolism and its effect on survival among patients with common cancers / Arch Intern Med 166 : 458 ~ 464
Chew HK / 2008 / The incidence of venous thromboembolism among patients with primary lung cancer / J Thromb Haemost 6 : 601 ~ 608
Czaykowski PM / 1998 / High risk of vascular events in patients with urothelial transitional cell carcinoma treated with cisplatin based chemotherapy / J Urol 160 (6Pt 1) :
Heit JA / 2000 / Risk factors for deep vein thrombosis and pulmonary embolism : a population-based case-control study / Arch Intern Med 160 : 809 ~ 815
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