지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 34 - 40 (7page)
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초록· 키워드
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Purpose: A retrospective study was performed o define
the clninical significance of p53, P-glycoprotein (Pgp),
and Glutathione S transferase-π (GST-π) immunohistochemical
(IHC) expression in advanced non-small cell
lung cancer (NSCLC).
Materials and Methods: We reviewed fifty seven
patients with advanced NSCLC who had undergone
surgical resection or bronchoscopic biopsy between
March 1997 and March 1999. IHC staining for p53, GST-π,
and Pgp was performed using formalin-fixed, paraffinembedded
specimens of the fifty seven patients.
Results: The IHC expression rate was 63% for p53, 28%
for Pgp, and 53% for GST-π, respectively. The median
survival of the fifty seven patients was 45 weeks and the
response rate was 38.6% (partial response, 22/57). The
chemotherapy response and median survival of the p53
negative group (57% and 61 weeks) were better than
those demonstrated by the p53 positive group (28%
and 21 weeks) (p＜0.05). Additionally, the GST-π negative
group showed a greater improvement of survival and
response rate than the positive group (p＜0.05). Pgp
expression status appeared to have no significant
differential effect on chemotherapy response and
survival.
Conclusion: These results suggest that immunohistochemical
staining of p53 and GST-π may be useful in
predicting the response to chemotherapy as well as
survival in advanced NSCLC. However, this study is
limited by its retrospective nature and the small numbers
of tumors studied from a heterogenous group of patients.
(Cancer Res Treat. 2002;34:34-40)
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