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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Seok Jeong (Department of Internal Medicine, Ewha Womans University School of Medicine) Kang, Hyun Ju (Department of Internal Medicine, Ewha Womans University School of Medicine) Kim, Seo Woo (Department of Internal Medicine, Ewha Womans University School of Medicine) Ryu, Yon Ju (Department of Internal Medicine, Ewha Womans University School of Medicine) Lee, Jin Hwa (Department of Internal Medicine, Ewha Womans University School of Medicine) Kim, Yookyung (Department of Radiology, Ewha Womans University School of Medicine) Chang, Jung Hyun (Department of Internal Medicine, Ewha Womans University School of Medicine)
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제77권 제1호
발행연도
2014.1
수록면
13 - 17 (5page)

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Background: This study analyzed the negative prognostic factors in patients who received second-line chemotherapy for advanced inoperable non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the records of 137 patients with inoperable stage III-IV NSCLC who received second-line chemotherapy. The effects of clinical parameters on survival were analyzed and the hazard ratios (HR) for mortality were identified by a Cox regression analysis. Results: Sex, age older than 65 years, smoking history, cell type, T-stage, best response to first-line chemotherapy and first-line chemotherapy regimen were significant negative predictors in univariate analysis. The multivariate analysis showed that patients older than 65 years (HR, 1.530; 95% confidence interval [CI], 1.020-2.297), advanced T stage (T4 vs. T1; HR, 2.273; 95% CI, 1.010-5.114) and non-responders who showed progression with first-line chemotherapy (HR, 1.530; 95% CI, 1.063-2.203) had higher HR for death. Conclusion: The age factor, T stage and responsiveness to first-line chemotherapy were important factors in predicting the outcome of patients with advanced NSCLC who received second-line chemotherapy. The results may help to predict outcomes for these patients in the future.

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