지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 41 - 45 (5page)
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초록· 키워드
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Purpose: There are increasing evidences that angiogenesis
enhances tumor growth and biological aggressiveness
in gastric carcinoma. Mast cells have been
implicated in the angiogenic process, by secreting
angiogenic factors including vascular endothelial growth
factor (VEGF), or enzymes that degrade extracellular
matrices. However, the exact nature of mast cells in
relation to cancer is contradictory so we conducted
retrospective studies, to find the significance of mast cell
densities, and microvessel counts in each clinicopathologic
factors, including VEGF expression, in proper
muscle (PM) gastric carcinoma.
Materials and Methods: 52 specimens, obtained from
patients with PM gastric carcinoma, were studied using
the immunohistochemical methods, monoclonal antibodies
for mast cell tryptase, factor VIII-related antigen
and VEGF.
Results: Mast cell densities were significantly increased
in diffuse histologic type (p=0.042), infiltrating
margins (p＜0.0001) and VEGF positive (p=0.010) tumors.
Microvessel counts were significantly higher in patients
over 55 years old (p=0.024), with tumor sizes larger than
＞3 cm (p=0.015), diffuse histologic type (p=0.038) and
lymph node metastasis (p=0.001). Similarly there were significantly
increased densities in VEGF positive tumors (p
＜0.0001). Pearson's correlation analysis revealed a
significant relationship between mast cell densities and
microvessel counts (r=0.614, p＜0.01), indicating a high
vascular grade with increased number of mast cells.
Conclusion: We demonstrated a close relationship
between mast cell densities, microvessel counts and
VEGF expression. These results suggest that mast cells
and VEGF are important regulators of tumor angiogenesis
and cooperatively induce the formation of vascular stroma
in PM gastric carcinomas. (Cancer Res Treat. 2002;34:41-45)
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