후두 편평상피암에서 β-catenin과 AdenomatousPolyposis Coli(APC) 단백의 발현

장혁순; 김효진; 박훈; 김동욱; 이병돈; 박진규

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자료유형: 학술저널

저자정보: 장혁순 김효진 박훈 김동욱 이병돈 박진규

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제3호

발행연도: 2005.1

수록면: 352 - 356 (5page)

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Background and Objectives：β-catenin has an esential role in intercellular adhesion and signal transduction. The Adeno-matous poliposis coli (APC) protein interacts with β-catenin in a multi-protein complex to regulate the level of expresion of β-catenin. Mutations in β-catenin or APC gene can lead to the accumulation of β-catenin in the cytosol and the nucleus. This study was designed to investigate the expresion of APC and β-catenin in laryngeal cancer. Subjects and Method：Imunohistochemical methods were used to determine the β-catenin and APC protein expresion in 15 laryngeal cancers. Re-sults were correlated with clinicopathological parameters. Results：β-catenin expression to the plasma membrane was reduced or absent in 11 of 15 cases (73% ) of the laryngeal cancers. Cytoplasmic expression of the β-catenin was seen in 6 out of 15 cases (40% ). APC imunoactivity was negative in 5 of 15 (33% ) of the laryngeal cancers. One of the six cytoplasmic expressions of the β-catenin was negative for APC imunoactivity, and one of the five negative for APC imunoactivity was cytoplasmic expresion of the β-catenin. Conclusion：There was no correlation between βanalysis. This finding sugests that cytoplasmic expression of the β-catenin resulted not from the APC mutation but from the β-catenin mutation and abnormal Wnt signal. Only the expression of the β-catenin in cytoplasm was associated with lymph node metastasis.

#β-catenin·선종성 결장 용종증 단백·후두암. #β-catenin· Adenomatous polyposis coli #APC) protein· Laryngeal neoplasms.

참고문헌 (17)

참고문헌 신청

/ / E-cadherin and α-catenin expression : 291 ~ 6

/ 195-209. / Flanders D. Epidemiology of laryngeal cancer.Epidemiol Rev 1980

/ 1996 / et al. β-catenin expression in human cancers. Am J Pathol 1996 : 39 ~ 46

/ 1997 / et al. Expression of E-cadherin : 158 ~ 65

/ 1998 / Adams GL. Malignant tumors of the larynx and hypopharynx. In : 19982130 ~ 75

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