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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 243 - 250 (8page)
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The cognitive impairment and neuroanatomical changes that takes place among patients with bipolar disorder (BD) patients has been well described. Recent data suggest that changes in neuroplasticity, cell resilience and connectivity are the main neuropathological findings in BD. Data from differential lines of research converges to the brain-derived neurotrophic factor (BDNF) as an important contributor to the neuroplasticity changes described among BD patients. BDNF serum levels have been shown to be decreased in depressive and manic episodes,returning to normal levels in euthymia. BDNF has also been shown to decrease as the disorder progresses. Moreover, factors that negatively influence the course of BD, such as life stress and trauma have been shown to be associated with a decrease in BDNF serum levels.
These findings suggest that BDNF plays a central role in the progression of BD. The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BDNF as a biomarker in BD.
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참고문헌 (23)
참고문헌 신청
Aid T / 2007 / Mouse and rat BDNF gene structure and expression revisited / J Neurosci Res 85 : 525 ~ 535
Barnett JH / 2009 / The genetics of bipolar disorder / Neuroscience 164 : 331 ~ 343
Chen ZY / 2005 / Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway / J Neurosci 25 : 6156 ~ 6166
Chen ZY / 2006 / Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior / Science 314 : 140 ~ 143
Dienes KA / 2006 / The stress sensitization hypothesis: understanding the course of bipolar disorder / J Affect Disord 95 : 43 ~ 49
Barnett JH / 2009 / The genetics of bipolar disorder / Neuroscience 164 : 331 ~ 343
Chen ZY / 2005 / Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway / J Neurosci 25 : 6156 ~ 6166
Chen ZY / 2006 / Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior / Science 314 : 140 ~ 143
Dienes KA / 2006 / The stress sensitization hypothesis: understanding the course of bipolar disorder / J Affect Disord 95 : 43 ~ 49
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