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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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초록· 키워드
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Objectives：Catechol-O-methyltransferase (COMT) gene has been identified as a positional and functional candidate gene of schizophrenia. Although specific mechanism of increasing schizophrenia susceptibility by this gene has not been well described yet, recent studies suggest that the valine allele of COMT Val158Met polymorphism may contribute to cognitive decline in schizophrenia. The present study investigated the association between this polymorphism of COMT gene and cognitive markers related to schizophrenia in both schizophrenia patients and normal controls.
Methods：The subjects were 78 patients with schizophrenia diagnosed by DSM-IV and 97 normal controls. Comprehensive neurocognitive tests for which performance deficits have been reported in schizophrenia were administered. Genotyping for COMT Val158Met polymorphism was done with SNapShot method. Association analyses between genotype and cognitive functions were performed using ANCOVA and MANCOVA.
Results：In the comparison of allele frequencies between patient and control groups, no significant association between the polymorphism and schizophrenia was observed. Significant differences of cognitive performance among genotype groups were not identified in control group. This trend was also observed in the patient group. In the combined analysis of both patient and control groups, there was no significant genotype or genotype-by group effect on any cognitive function measure.
Conclusion：These findings do not support a major role of COMT gene in the regulation of the cognitive processes of schizophrenia. (J Korean Neuropsychiatr Assoc 2008;47(2):126-133)
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Chen CH / 1999 / Systematic mutation analysis of the catechol O-methyltransferase gene as a candidate gene for schizophrenia / Am J Psychiatry 156 : 1273 ~ 1275
Daniels JK / 1996 / No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity / Am J Psychia
Egan MF / 2001 / Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia / Proc Natl Acad Sci U S A 98 : 6917 ~ 6922
Fan JB / 2005 / Catechol- O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis / Biol Psych
Flint J / 2007 / The endophenotype concept in psychiatric genetics /
Daniels JK / 1996 / No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity / Am J Psychia
Egan MF / 2001 / Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia / Proc Natl Acad Sci U S A 98 : 6917 ~ 6922
Fan JB / 2005 / Catechol- O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis / Biol Psych
Flint J / 2007 / The endophenotype concept in psychiatric genetics /
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정신분열병과 Catechol-O-methyltransferase(COMT) 유전자 다형성의 연합
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