지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 215 - 219 (5page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaPanic disorder (PD) is a common and often chronic psychiatric illness, and serotonin-specific reuptake inhibitors (SSRIs) are the drugs of choice for the treatment of PD. Previous studies suggested the cerebral cortex and limbic brain structures played a major role in the development of PD, but the therapeutic effect of SSRIs on specific brain structures remains unclear in PD. We examined the changes in PD patients’ glucose metabolism using the [18F] Fluorodeoxy-glucose-positron emission tomography (FDG-PET) before and after 12 weeks of paroxetine treatment.
MethodsaaWe assessed the brain glucose metabolism of 5 PD patients, using the [18F]FDG-PET, and treated them with paroxetine (12.5-37.5 mg/day) for 12 weeks. Then, we compared before and after treatment PET images of the patients, using voxel-based statistical analysis and a post hoc regions of interest analysis. Furthermore, we measured the patients’ clinical variables, including information from the Panic Disorder Severity Scale (PDSS), Clinical Global Impression for Severity (CGI-S), and Hamilton Anxiety Rating Scale (HAMA).
ResultsaaAfter 12 weeks of paroxetine treatment, the patients showed significant clinical improvement in terms of PDSS, CGI-S and HAMA scores (12.8±1.8 vs. 3.8±2.3, 4.6±0.5 vs. 2.0±1.4, and 15.2±4.0 vs. 5.0±1.2, respectively; all p values<0.05). After treatment, patients’ glucose metabolism increased significantly in global brain areas: the right precentral gyrus, right middle frontal gyrus, right amygdala, right caudate body, right putamen, left middle frontal gyrus, left precentral gyrus, left insula, left parahippocampal gyrus, and left inferior frontal gyrus (All areas were significant at uncorrected p<0.001 and cluster level corrected p<0.05).
ConclusionaaIn these PD patients, cerebral cortex and limbic brain functions changed after short-term treatment with paroxetine. The therapeutic action of paroxetine may be related to altered glucose metabolism at both the cerebral cortex and limbic brain areas.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 1998 / Practice guideline for the treatment of patients with panic disorder. Work Group on Panic Disorder / Am J Psychiatry 155 (5) : 1 ~ 34
Allman JM / 2001 / The anterior cingulate c
Altshuler LL / 1991 / Assessment of affective variables in clinical trials in Handbook of Clinical Trials: The Neurobehavioral Approach / Netherlands Publishers : 141 ~ 164
Bisaga A / 1998 / Cerebral glucose metabolism in women with panic disorder / Am J Psychiatry 155 : 1178 ~ 1183
Boshuisen ML / 2002 / rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest / Biol Psychiatry 52 : 126 ~ 135
Allman JM / 2001 / The anterior cingulate c
Altshuler LL / 1991 / Assessment of affective variables in clinical trials in Handbook of Clinical Trials: The Neurobehavioral Approach / Netherlands Publishers : 141 ~ 164
Bisaga A / 1998 / Cerebral glucose metabolism in women with panic disorder / Am J Psychiatry 155 : 1178 ~ 1183
Boshuisen ML / 2002 / rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest / Biol Psychiatry 52 : 126 ~ 135
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