지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 84 - 88 (5page)
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초록· 키워드
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Purpose: Neurofibromatosis type 1 (NF1), which is caused by mutations of the NF1 gene, is the most frequent single gene disorder to affect the nervous system. Unidentified bright objects (UBOs) are commonly observed on brain magnetic resonance imaging (MRI) in patients with NF1. However, their clinical and pathologic significance is not well understood. The purpose of this study was to investigate the correlation between UBOs and cerebral glucose metabolism measured by $^{18}F$-2-Fluoro-2-deoxy-D-glucose ($^{18}F$-FDG) positron emission tomography (PET) in Korean patients with NF1. Materials and Methods: Medical records of 75 patients (34 males and 41 females) with NF1 who underwent brain MRI and PET between 2005 and 2011 were evaluated retrospectively. Clinical data including demographics, neurological symptoms, and brain MRI and PET findings, were reviewed. Results: UBOs were detected in the brain MRI scans of 31 patients (41%). The region most frequently affected by UBOs was the basal ganglia. The most frequent brain PET finding was thalamic glucose hypometabolism (45/75, 60%). Of the 31 patients with UBOs, 26 had thalamic glucose hypometabolism on brain PET, but the other 5 had normal brain PET findings. Conversely, of the 45 patients with thalamic glucose hypometabolism on brain PET, 26 showed UBOs on their brain MRI scans, but 19 had normal findings on brain MRI scans. Conclusion: UBOs on brain MRI scans and thalamic glucose hypometabolism on PET appear to be 2 distinctive features of NF1 rather than correlated symptoms. Because the clinical significance of these abnormal imaging findings remains unclear, a longitudinal follow-up study of changes in clinical manifestations and imaging findings is necessary.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Huson SM / 1988 / Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales / Brain 111:1355~1381
Moharir M / 2010 / Utility of positron emission tomography for tumour surveillance in children with neurofibromatosis type 1 / Eur J Nucl Med Mol Imaging 37:1309~1317
Griffiths PD / 1999 / Neurofibromatosis bright objects in children with neurofibromatosis type 1: a proliferative potential? / Pediatrics 104:49
Margari L / 2006 / Clinical and instrumental (magnetic resonance imaging [MRI] and multimodal evoked potentials) follow-up of brain lesions in three young patients with neurofibromatosis 1 / J Child Neurol 21:1085~1090
DiPaolo DP / 1995 / Neurofibromatosis type 1: pathologic substrate of high-signalintensity foci in the brain / Radiology 195:721~724
Moharir M / 2010 / Utility of positron emission tomography for tumour surveillance in children with neurofibromatosis type 1 / Eur J Nucl Med Mol Imaging 37:1309~1317
Griffiths PD / 1999 / Neurofibromatosis bright objects in children with neurofibromatosis type 1: a proliferative potential? / Pediatrics 104:49
Margari L / 2006 / Clinical and instrumental (magnetic resonance imaging [MRI] and multimodal evoked potentials) follow-up of brain lesions in three young patients with neurofibromatosis 1 / J Child Neurol 21:1085~1090
DiPaolo DP / 1995 / Neurofibromatosis type 1: pathologic substrate of high-signalintensity foci in the brain / Radiology 195:721~724
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