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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 264 - 271 (8page)
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초록· 키워드
오류제보하기
Objective: Recent neuroimaging studies have suggested that brain changes occur in subjects at ultra-high risk (UHR) for psychosis while experiencing prodromal symptoms, among which depression may increase the risk of developing a psychotic disorder. The goal of this study is to examine brain metabolite levels in the anterior cingulate cortex, the left dorsolateral prefrontal cortex and the left thalamus in subjects at UHR for psychosis and to compare brain metabolite levels between the UHR subjects with comorbid major depressive disorder and healthy controls.
Methods: Proton magnetic resonance spectroscopy was used to examine brain metabolite levels. Twenty UHR subjects and 20 age- and intelligence quotient (IQ)-matched healthy controls were included in this study.
Results: Overall, no significant differences were observed in any metabolite between the UHR and healthy control group. However, UHR subjects with major depressive disorder showed significantly higher myo-inositol (Ins) levels in the left thalamus, compared to the healthy control.
Conclusion: Our results demonstrate that increased thalamic Ins level is associated with prodromal depressive symptoms. Further longitudinal follow-up studies with larger UHR sample sizes are required to investigate the function of Ins concentrations as a biomarker of vulnerability to psychosis.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aydin K / 2008 / Altered metabolic integrity of corpus callosum among individuals at ultra high risk of schizophrenia and firstepisode patients / Biol Psychiatry 64 : 750 ~ 7
Borgwardt SJ / 2007 / Regional gray matter volume abnormalities in the at risk mental state / Biol Psychiatry 61 : 1148 ~ 1156
Caetano SC / 2005 / Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients / Neurosci Lett 384 : 321 ~ 326
Choi JS / 2008 / Cavum septum pellucidum in subjects at ultra-high risk for psychosis:compared with first-degree relatives of patients with schizophrenia and healthy volunte
Farchione TR / 2002 / Proton magnetic resonance spectroscopic imaging in pediatric major depression / Biol Psychiatry 52 : 86 ~ 92
Borgwardt SJ / 2007 / Regional gray matter volume abnormalities in the at risk mental state / Biol Psychiatry 61 : 1148 ~ 1156
Caetano SC / 2005 / Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients / Neurosci Lett 384 : 321 ~ 326
Choi JS / 2008 / Cavum septum pellucidum in subjects at ultra-high risk for psychosis:compared with first-degree relatives of patients with schizophrenia and healthy volunte
Farchione TR / 2002 / Proton magnetic resonance spectroscopic imaging in pediatric major depression / Biol Psychiatry 52 : 86 ~ 92
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