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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 81 - 91 (11page)
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ObjectiveaaAntidepressants are known to positively influence several factors in patients with depressive disorders, resulting in increased neurogenesis and subsequent relief of depressive disorders. To study the effects of venlafaxine during neural differentiation at the cellular level, we looked at its effect on protein expression and regulation mechanisms during neural differentiation.
MethodsaaAfter exposing NCCIT cell-derived EBs to venlafaxine during differentiation (1 day and 7 days), changes in protein expression were analyzed by 2-DE and MALDI-TOF MS analysis. Gene levels of proteins regulated by venlafaxine were analyzed by real-time RT-PCR.
ResultsaaTreatment with venlafaxine decreased expression of prolyl 4-hydroxylase (P4HB), ubiquitin-conjugating enzyme E2K (HIP2) and plastin 3 (T-plastin), and up-regulated expression of growth factor beta-3 (TGF-β3), dihydropyrimidinase-like 3 (DPYSL3), and pyruvate kinase (PKM) after differentiation for 1 and 7 days. In cells exposed to venlafaxine, the mRNA expression patterns of HIP2 and PKM, which function as negative and positive regulators of differentiation and neuronal survival, respectively, were consistent with the observed changes in protein expression.
ConclusionaaOur findings may contribute to improve understanding of molecular mechanism of venlafaxine.
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참고문헌 (25)
참고문헌 신청
Boyer LA / 2005 / Core transcriptional regulatory circuitry in human embryonic stem cells / Cell 122 : 947 ~ 956
Bremner JD / 2000 / Hippocampal volume reduction in major depression / Am J Psychiatry 157 : 115 ~ 118
Cecconi D / 2007 / Proteomic analysis of rat cortical neurons after fluoxetine treatment / Brain Res 1135 : 41 ~ 51
Chiou SH / 2006 / Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell / Biochem
Damjanov I / 1993 / Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT / Lab Invest 68 : 220 ~ 232
Bremner JD / 2000 / Hippocampal volume reduction in major depression / Am J Psychiatry 157 : 115 ~ 118
Cecconi D / 2007 / Proteomic analysis of rat cortical neurons after fluoxetine treatment / Brain Res 1135 : 41 ~ 51
Chiou SH / 2006 / Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell / Biochem
Damjanov I / 1993 / Retinoic acid-induced differentiation of the developmentally pluripotent human germ cell tumor-derived cell line, NCCIT / Lab Invest 68 : 220 ~ 232
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