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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 58 - 62 (5page)
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초록· 키워드
오류제보하기
ObjectiveaaThis retrospective case series study of the effectiveness of electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review.
MethodsaaClozapine-resistance was defined as persistent psychotic symptoms despite at least 12 weeks of clozapine administration with blood levels over 350 ng/mL in order to rule out pseudo-resistance. Seven in-patients who were taking clozapine and treated with ECT were selected. We analyzed the psychopathology and subscales changed by ECT.
ResultsaaThe average number of ECT sessions was 13.4 (±4.6). Total Positive and Negative Syndrome Scale (PANSS) score was significantly reduced by 17.9 (±12.8) points (p=0.0384) on average, which represented a reduction of 25.5% (±14.3). 71.4% (5/7) of patients were identified as clinical remission, with at least a 20% reduction in PANSS score. PANSS reduction was associated with number of ECT sessions, stimulus level in the final session, and blood clozapine levels before ECT. However, the negative subscale on the PANSS were not reduced by ECT in any patient. We did not observe any persistent adverse cognitive effects.
ConclusionaaThis study supports that ECT augmentation on clozapine-resistant schizophrenia reveals clinically effective and safe. Further research should be done involving a larger number of patients to investigate the effectiveness of clozapine/ECT combination therapy.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Dold M / 2014 / Pharmacotherapy of treatment-resistant schizophrenia : a clinical perspective / Evid Based Ment Health 17:33~37
Juarez-Reyes MG / 1995 / Effects of stringent criteria on eligibility for clozapine among public mental health clients / Psychiatr Serv 46:801~806
Meltzer HY / 1997 / Treatment-resistant schizophrenia--the role of clozapine / Curr Med Res Opin 14:1~20
Petrides G / 2015 / Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study / Am J Psychiatry 172:52~58
Remington G / 2005 / Augmentation strategies in clozapine-resistant schizophrenia / CNS Drugs 19:843~872
Juarez-Reyes MG / 1995 / Effects of stringent criteria on eligibility for clozapine among public mental health clients / Psychiatr Serv 46:801~806
Meltzer HY / 1997 / Treatment-resistant schizophrenia--the role of clozapine / Curr Med Res Opin 14:1~20
Petrides G / 2015 / Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study / Am J Psychiatry 172:52~58
Remington G / 2005 / Augmentation strategies in clozapine-resistant schizophrenia / CNS Drugs 19:843~872
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