지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Major depressive disorder (MDD) is a common disorder, widely distributed in the population, and usually associated with substantial symptom severity and role impairment. MDD is also a complex and heterogeneous disorder, at etiological, phenotypical, and biological levels. The gene or series of genes, which cause MDD, have so far not been identified. However, certain genetic variations, called polymorphisms, may increase the risk of MDD in a susceptible person. In addition, environmental stress also is a common precipitating factor of MDD. Various stressful life-experiences-prenatal stress, aversive early life experiences, ongoing or recent psychosocial stress-are important en-vironmental factors contributing to the development of MDD. Nevertheless, not all persons ex-posed to these stresses become depressed. Environmental stress interacts with a person’s ge-netic makeup to influence his or her risk for developing MDD. It is the combination of genes, early life stress, and ongoing stress, which may ultimately determine an individual’s responsiveness to stress and vulnerability to MDD. Consequently, the gene and environment interactions may impact multiple neurobiological systems implicated in MDD. The gene-environment interaction in the pa-thophysiology of MDD leads to advances in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Such concept may explain why some subjects become depressed while others remain unaffected.
목차
등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Martinowich K / 2008 / Interaction between BDNF and serotonin: role in mood disorders / Neuropsychopharmacology 33:73~83
Bath KG / 2006 / Variant BDNF (Val66Met) impact on brain structure and function / Cogn Affect Behav Neurosci 6:79~85
Duman RS / 2006 / A neurotrophic model for stress-related mood disorders / Biol Psychiatry 59:1116~1127
Martinowich K / 2007 / New insights into BDNF function in depression and anxiety / Nat Neurosci 10:1089~1093
Pezawas L / 2004 / The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology / J Neurosci 24:10099~10102
Bath KG / 2006 / Variant BDNF (Val66Met) impact on brain structure and function / Cogn Affect Behav Neurosci 6:79~85
Duman RS / 2006 / A neurotrophic model for stress-related mood disorders / Biol Psychiatry 59:1116~1127
Martinowich K / 2007 / New insights into BDNF function in depression and anxiety / Nat Neurosci 10:1089~1093
Pezawas L / 2004 / The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology / J Neurosci 24:10099~10102
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