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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 344 - 349 (6page)
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Objective: α-synuclein, Nogo-A and Ubiquitin C-terminal hydrolase L1 (UCH-L1) have neuromodulatory roles for human brain. Therefore, abnormalities of these molecules are associated with neuropsychiatric disorders. Although some serum studies in the other disorders have been made, serum study of α-synuclein, Nogo-A and UCH-L1 is not present in patients with schizophrenia and healthy controls. Therefore, our aim was to compare serum levels of α-synuclein, Nogo-A and UCH-L1 of the patients with schizophrenia and healthy controls.
Methods: Forty-four patients with schizophrenia who is followed by psychotic disorders unit, and 40 healthy control were included in this study. Socio-demographic form and Positive and Negative Syndrome Scale (PANSS) was applied to patients, and sociodemographic form was applied to control group. Fasting bloods were collected and the serum levels of α-synuclein, Nogo-A and UCH-L1 were measured by ELISA method.
Results: Serum α-synuclein [patient: 12.73 (5.18–31.84) ng/mL; control: 41.77 (15.12–66.98) ng/mL], Nogo-A [patient: 33.58 (3.09–77.26) ng/mL; control: 286.05 (136.56–346.82) ng/mL] and UCH-L1 [patient: 5.26 (1.64–10.87) ng/mL; control: 20.48 (11.01–20.81) ng/mL] levels of the patients with schizophrenia were significianly lower than healthy controls (p<0.001).
Conclusion: Our study results added new evidence for explaining the etiopathogenesis of schizophrenia on the basis of neurochemical markers.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Novak G / 2002 / Schizophrenia and Nogo: elevated mRNA in cortex, and high prevalence of a homozygous CAA insert / Brain Res Mol Brain Res 107:183~189
Tan HY / 2008 / Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans / J Clin Invest 118:2200~2208
Novak G / 2006 / Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3’-UTR / Brain Res 1120:161~171
Ng MY / 2009 / Meta-analysis of 32 genome-wide linkage studies of schizophrenia / Mol Psychiatry 14:774~785
Wilkinson KD / 1989 / The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase / Science 246:670~673
Tan HY / 2008 / Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans / J Clin Invest 118:2200~2208
Novak G / 2006 / Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3’-UTR / Brain Res 1120:161~171
Ng MY / 2009 / Meta-analysis of 32 genome-wide linkage studies of schizophrenia / Mol Psychiatry 14:774~785
Wilkinson KD / 1989 / The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase / Science 246:670~673
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