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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 458 - 467 (10page)
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초록· 키워드
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ObjectiveaaThe purpose of this study was to investigate the efficacy and tolerability of atypical antipsychotics (AAPs) with augmentation by blonanserin in schizophrenic patients.
MethodsaaA total of 100 patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP were recruited in this 12-week, open-label, non-comparative, multicenter study. Blonanserin was added to their existing AAP regimen, which was maintained during the study period. Efficacy was primarily evaluated using the Positive and Negative Syndrome Scale (PANSS) at baseline and at weeks 2, 4, 8, and 12. Predictors for PANSS response (≥20% reduction) were investigated.
ResultsaaThe PANSS total score was significantly decreased at 12 weeks of blonanserin augmentation (-21.0±18.1, F=105.849, p<0.001).
Moreover, 51.0% of participants experienced a response at week 12. Premature discontinuation of blonanserin occurred in 17 patients (17.0%); 4 of these patients dropped out due to adverse events. The patients who benefited the most from blonanserin were those with severe symptoms despite a treatment with a higher dose of AAP.
ConclusionaaBlonanserin augmentation could be an effective strategy for patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP.
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등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Kirkpatrick B / 2006 / The NIMHMATRICS consensus statement on negative symptoms / Schizophr Bull 32:214~219
De Hert M / 2007 / Remission criteria for schizophrenia : evaluation in a large naturalistic cohort / Schizophr Res 92:68~73
Hegarty JD / 1994 / One hundred years of schizophrenia : a meta-analysis of the outcome literature / Am J Psychiatry 151:1409~1416
Lieberman JA / 2005 / Effectiveness of antipsychotic drugs in patients with chronic schizophrenia / N Engl J Med 353:1209~1223
김희윤 / 2014 / Prescription Patterns for Patients with Schizophrenia in Korea: A Focus on Antipsychotic Polypharmacy / Clinical Psychopharmacology and Neuroscience 12(2):128~136
De Hert M / 2007 / Remission criteria for schizophrenia : evaluation in a large naturalistic cohort / Schizophr Res 92:68~73
Hegarty JD / 1994 / One hundred years of schizophrenia : a meta-analysis of the outcome literature / Am J Psychiatry 151:1409~1416
Lieberman JA / 2005 / Effectiveness of antipsychotic drugs in patients with chronic schizophrenia / N Engl J Med 353:1209~1223
김희윤 / 2014 / Prescription Patterns for Patients with Schizophrenia in Korea: A Focus on Antipsychotic Polypharmacy / Clinical Psychopharmacology and Neuroscience 12(2):128~136
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