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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 851 - 863 (13page)
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초록· 키워드
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Objective: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (KBASE) aimed to recruit 650 individuals, aged from 20 to 90 years, to search for new biomarkers of Alzheimer’s disease (AD) and to investigate how multi-faceted lifetime experiences and bodily changes contribute to the brain changes or brain pathologies related to the AD process.
Methods: All participants received comprehensive clinical and neuropsychological evaluations, multi-modal brain imaging, including magnetic resonance imaging, magnetic resonance angiography, [11C]Pittsburgh compound B-positron emission tomography (PET), and [18F]fluorodeoxyglucose-PET, blood and genetic marker analyses at baseline, and a subset of participants underwent actigraph monitoring and completed a sleep diary. Participants are to be followed annually with clinical and neuropsychological assessments, and biannually with the full KBASE assessment, including neuroimaging and laboratory tests.
Results: As of March 2017, in total, 758 individuals had volunteered for this study. Among them, in total, 591 participants–291 cognitively normal (CN) old-aged individuals, 74 CN young- and middle-aged individuals, 139 individuals with mild cognitive impairment (MCI), and 87 individuals with AD dementia (ADD)–were enrolled at baseline, after excluding 162 individuals. A subset of participants (n=275) underwent actigraph monitoring.
Conclusion: The KBASE cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (CN, MCI, and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bertram L / 2016 / Systems Biology of Alzheimer’s Disease / Springer New York : 281 ~ 297
Blennow K / 2010 / Biomarkers in Alzheimer’s disease drug development / Nat Med 16 : 1218 ~ 1222
Brookmeyer R / 1998 / Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset / Am J Public Health 88 : 1337 ~ 1342
Brookmeyer R / 2007 / Forecasting the global burden of Alzheimer’s disease / Alzheimers Dement 3 : 186 ~ 191
Doody RS / 2014 / Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease / N Engl J Med 370 : 311 ~ 321
Blennow K / 2010 / Biomarkers in Alzheimer’s disease drug development / Nat Med 16 : 1218 ~ 1222
Brookmeyer R / 1998 / Projections of Alzheimer’s disease in the United States and the public health impact of delaying disease onset / Am J Public Health 88 : 1337 ~ 1342
Brookmeyer R / 2007 / Forecasting the global burden of Alzheimer’s disease / Alzheimers Dement 3 : 186 ~ 191
Doody RS / 2014 / Phase 3 trials of solanezumab for mild-to-moderate Alzheimer’s disease / N Engl J Med 370 : 311 ~ 321
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