지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 216 - 221 (6page)
이용수
초록· 키워드
오류제보하기
Objective: The aim of this study was to evaluate the association between a variable number of tandem repeats polymorphism at the dopamine D4 receptor gene (DRD4) and the performance of children with attention deficit hyperactivity disorder (ADHD) in a continuous performance test (CPT).
Methods: This study included 72 ADHD children (mean age=9.39±2.05 years) who were recruited from one child psychiatric clinic. The omission errors, commission errors, reaction time and reaction standardization in the CPT were computed. The number of 48-base pairs tandem repeats in the exon III of DRD4 was analyzed in a blind manner.
Results: The homozygosity of the 4-repeat allele at DRD4 was significantly associated with fewer commission errors (t=2.364, df=28.685, p=0.025) and standard deviation of reaction time (t=2.351, df=24.648, p=0.027) even after adjusting for age. The results of analyses of CPT measured values among three groups showed that the group with higher frequency of the 4-repeat allele showed a lower mean score of commission errors (F=4.268, df=2,
p=0.018).
Conclusion: These results suggest a protective role of 4-repeat allele of the DRD4 polymorphisms on commission errors in the CPT in children with ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Asghari V / 1995 / Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants / J Neurochem 65 : 1157 ~ 1656
Barkley RA / 1992 / Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report / J Abnorm Child Psychol 20 : 163 ~ 188
Biederman J / 1996 / Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study / J Am Acad Child Adolesc Psychiat
Casey BJ / 1997 / Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder / J Am Acad Child Adolesc Psychiatry 36 :
Ding YC / 2002 / Evidence of positive selection acting at the human dopamine receptor D4 gene locus / Proc Natl Acad Sci : 309 ~ 314
Barkley RA / 1992 / Frontal lobe functions in attention deficit disorder with and without hyperactivity: a review and research report / J Abnorm Child Psychol 20 : 163 ~ 188
Biederman J / 1996 / Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study / J Am Acad Child Adolesc Psychiat
Casey BJ / 1997 / Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder / J Am Acad Child Adolesc Psychiatry 36 :
Ding YC / 2002 / Evidence of positive selection acting at the human dopamine receptor D4 gene locus / Proc Natl Acad Sci : 309 ~ 314
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한국인 주의력결핍 과잉행동장애와 도파민 D5 수용체 유전자 다형성의 관련성 : 가족기반 연구 및 환자-대조군 연구
신경정신의학
2005 .01
-
No Association between the Response to Methylphenidate and DRD4 Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder: A Case Control Study
Clinical Psychopharmacology and Neuroscience
2013 .01
-
주의력결핍 과잉행동장애에서 도파민 전달체 및 도파민 D2, D3, D4 수용체 유전자 다형성
소아청소년정신의학
2008 .02
-
한국인 주의력결핍 과잉행동장애 아동에서 도파민 D4 수용체 유전자의 Variable Number of Tandem Repeats (VNTR) 다형성과 Methylphenidate 치료 반응간의 연관성
신경정신의학
2005 .01
-
Serotonin 2A Receptor Gene Polymorphism in Korean Children with Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2012 .01
-
한국인 정신분열병 환자에서 항정신병 약물의 치료 반응과 도파민 D2, D3 및 D4 수용체 유전자 다형성
생물정신의학
2007 .01
-
틱장애와 도파민 D2 수용체 유전자와의 연합 연구
생물정신의학
2006 .01
-
알코올 중독에서의 도파민 수용체 유전자 다형성
생물정신의학
2002 .01
-
한국인 주의력결핍 과잉행동장애와 세로토닌 1B 수용체 유전자 다형성의 관련성:가족기반 연구 및 환자-대조군 연구
생물정신의학
2004 .01
-
Dopamine Receptor Gene (DRD1-DRD5) Expression Changes as Stress Factors Associated with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Genetic Polymorphisms in Dopamine- and Serotonin-Related Genes and Treatment Responses to Risperidone and Perospirone
PSYCHIATRY INVESTIGATION
2009 .01
-
도파민 수용체 제 4형 Exon Ⅲ 다형성과 주의력결핍 과잉운동장애의 연합연구
소아청소년정신의학
2007 .10
-
주의력결핍 과잉행동장애 하위 유형별 연속수행과제 양상의 예비 연구
소아청소년정신의학
2008 .06
-
정신분열병에서 도파민 D4 수용체(DRD4) 유전자의 다형성
생물정신의학
2000 .01
-
정신분열병과 DRD3, DRD4, HTR2A 유전자 다형성의 연합연구
Annals of Laboratory Medicine
2004 .01
-
Gender-Specific Association of the Brain-Derived Neurotrophic Factor Gene with Attention-Deficit/Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2010 .01
-
주의력결핍 과잉행동장애에서 도파민 운반체 유전자의 10-Repeat Allele Homozygosity와 [¹²³I]IPT SPECT로 측정한 도파민 운반체 밀도가 Methylphenidate 치료 반응에 미치는 영향
신경정신의학
2004 .01
-
Quantitative Electroencephalography Reflects Inattention, Visual Error Responses, and Reaction Times in Male Patients with Attention Deficit Hyperactivity Disorder
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Association between GABA3 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children
PSYCHIATRY INVESTIGATION
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0