지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives：In the present study, we investigate the association between homozygosity of the 4-repeat allele (4/4) at the DRD4 and the response to the treatment with MPH in Korean children with ADHD.
Methods：The present study included 71 children with ADHD (8.231.78 years) from two children’s psychiatric clinics in South Korea. All drug-naive children with ADHD were treated with MPH for about 8 weeks. The subjects who showed improvement of over 50% compared with the baseline ARS score after 8 weeks of treatment were termed as the ‘good response’ group. The subjects who showed an improvement of less than 50% were considered as the ‘poor response’ group. After genotyping for DRD4 were performed, we investigated correlation between homozygosity for 4-repeat allele at DRD4 and the response to MPH treatment.
Results：We found that while 79.5% (31/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 68.8% (22/32) of the subjects without homozygosity of 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their parents (χ2=16.762, df=1, p<0.01). We also found that while 61.5% (24/39) of the subjects with homozygosity of4-repeat allele at DRD4 showed good response to MPH treatment, 87.5% (28/32) of the subjects without homozygosity of the 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their teachers (χ2=17.698, df=1, p<0.01).
Conclusion：Our findings support an association between the homozygosity of 4-repeat allele and a good response to MPH in ADHD of Koreans.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ / Adultoutcome of hyperactive boys : 565 ~ 576
/ 1980 / 소아정신과와 소아과 외래환자의 과잉행동에 관한 연구 23 : 51 ~ 57
/ 1989 / Correlates,associated impairmentsand patterns of service utilization of children with attentiondeificit disorder:findings from the Ontario Child Health Study 30 : 20
/ 1990 / Critique of current diagnostic criteria for attention deficithyperactivity disorder:clinical and research implications 11 : 343 ~ 352
/ 1991 / 파탄적 행동장애의 유병률에 대한 연구 41 : 141 ~ 149
/ 1980 / 소아정신과와 소아과 외래환자의 과잉행동에 관한 연구 23 : 51 ~ 57
/ 1989 / Correlates,associated impairmentsand patterns of service utilization of children with attentiondeificit disorder:findings from the Ontario Child Health Study 30 : 20
/ 1990 / Critique of current diagnostic criteria for attention deficithyperactivity disorder:clinical and research implications 11 : 343 ~ 352
/ 1991 / 파탄적 행동장애의 유병률에 대한 연구 41 : 141 ~ 149
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
주의력결핍 과잉행동장애에서 도파민 운반체 유전자의 10-Repeat Allele Homozygosity와 [¹²³I]IPT SPECT로 측정한 도파민 운반체 밀도가 Methylphenidate 치료 반응에 미치는 영향
신경정신의학
2004 .01
-
No Association between the Response to Methylphenidate and DRD4 Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder: A Case Control Study
Clinical Psychopharmacology and Neuroscience
2013 .01
-
Association between Dopamine D4 Receptor Gene Polymorphism and Scores on a Continuous Performance Test in Korean Children with Attention Deficit Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2009 .01
-
한국인 주의력결핍 과잉행동장애와 도파민 D5 수용체 유전자 다형성의 관련성 : 가족기반 연구 및 환자-대조군 연구
신경정신의학
2005 .01
-
정신분열병과 DRD3, DRD4, HTR2A 유전자 다형성의 연합연구
Annals of Laboratory Medicine
2004 .01
-
Variability of Response Time as a Predictor of Methylphenidate Treatment Response in Korean Children with Attention Deficit Hyperactivity Disorder
Yonsei Medical Journal
2009 .01
-
한국인 정신분열병 환자에서 항정신병 약물의 치료 반응과 도파민 D2, D3 및 D4 수용체 유전자 다형성
생물정신의학
2007 .01
-
주의력결핍 과잉행동장애에서 오로스 메칠페니데이트의 효용성
소아청소년정신의학
2012 .10
-
The Effects of Methylphenidate on Neural Substrates Associated with Interference Suppression in Children with ADHD: A Preliminary Study Using Event Related fMRI
PSYCHIATRY INVESTIGATION
2010 .01
-
주의력결핍과잉행동장애에서 Alpha-2A-Adrenergic 수용체 유전자와 Methylphenidate 반응과의 연관성에 대한 연구
신경정신의학
2011 .01
-
도파민 D2 수용체 다형성과 보상의존성 성격특성과의 관련성
생물정신의학
2004 .01
-
The Alpha-2A Adrenergic Receptor Gene -1291C/G Single Nucleotide Polymorphism is Associated with the Efficacy of Methylphenidate in Treating Taiwanese Children and Adolescents with Attention-Deficit Hyperactivity Disorder
PSYCHIATRY INVESTIGATION
2018 .01
-
Effect of Methylphenidate on Sleep Parameters in Children with ADHD
PSYCHIATRY INVESTIGATION
2012 .01
-
Preliminary Investigation of Association between Methylphenidate and Serum Growth Markers in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Case-Control Study
소아청소년정신의학
2020 .07
-
주의력결핍 과잉행동장애에서 도파민 전달체 및 도파민 D2, D3, D4 수용체 유전자 다형성
소아청소년정신의학
2008 .02
-
주의력결핍/과잉행동장애와 도파민 D4 수용체 촉진자 부위 -521C/T 다형성과의 연관성
생물치료정신의학
2007 .12
-
Switching from Methylphenidate-Immediate Release (MPH-IR) to Methylphenidate- OROS (OROS-MPH): A Multi-center, Open-label Study in Korea
Clinical Psychopharmacology and Neuroscience
2011 .01
-
ADHD 환자에 대한 OROS-Methylphenidate 약물치료의 부작용과 관련요인들에 대한 연구
소아청소년정신의학
2010 .06
-
Genetic Polymorphisms in Dopamine- and Serotonin-Related Genes and Treatment Responses to Risperidone and Perospirone
PSYCHIATRY INVESTIGATION
2009 .01
-
한국인 뚜렛 장애에서의 약물 반응과 도파민 유전자 다형성간의 상관관계에 대한 예비 연구
생물치료정신의학
2006 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0