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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 269 - 277 (9page)
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초록· 키워드
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Objective The purpose of this study was to investigate the association between the T102C polymorphism in the serotonin 2A receptor gene and attention-deficit/hyperactivity disorder (ADHD) in Korean patients.
Methods A total of 189 Korean children with ADHD as well as both parents of the ADHD children and 150 normal children participated in this study. DNA was extracted from blood samples from all of the subjects, and genotyping was conducted. Based on the allele and genotype information obtained, case-control analyses were performed to compare the ADHD and normal children, and Transmission disequilibrium tests (TDTs) were used for family-based association testing (number of trios=113). Finally, according to the significant finding which was showed in the case-control analyses, the results of behavioral characterastics and neuropsychological test were compared between ADHD children with and without the C allele.
Results In the case-control analyses, statistically significant differences were detected in the frequencies of genotypes containing the C allele (χ2=4.73, p=0.030). In the family-based association study, TDTs failed to detect linkage disequilibrium of the T102C polymorphism associated with ADHD children. In the ADHD children, both the mean reaction time and the standard deviation of the reaction time in the auditory continuous performance test were longer in the group with the C allele compared to the group without the C allele.
ConclusionaaThe results of this study suggest that there is a significant genetic association between the T102C polymorphism in the serotonin 2A receptor gene and ADHD in Korean children.
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참고문헌 (24)
참고문헌 신청
Achen
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders, 4th Edition / American Psychiatric Press
Cho SC. / 2008 / Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample / Neurosci Lett 446 : 108 ~ 111
Cho SC. / 2008 / Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder / Am J Med Genet B N
Collier DA. / 1997 / Association between 5-HT2A gene promoter polymorphism and anorexia nervosa / Lancet 350 : 412 ~
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders, 4th Edition / American Psychiatric Press
Cho SC. / 2008 / Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample / Neurosci Lett 446 : 108 ~ 111
Cho SC. / 2008 / Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder / Am J Med Genet B N
Collier DA. / 1997 / Association between 5-HT2A gene promoter polymorphism and anorexia nervosa / Lancet 350 : 412 ~
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