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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 49 - 54 (6page)
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초록· 키워드
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Objective: The core deficit of attention deficit hyperactivity disorder (ADHD) is associated with frontal cortex and related circuitry. Children with ADHD and a medication history have shown atypical brain activation in prefrontal and striatal brain regions during cognitive challenge.
We investigated two cognitive control operations such as interference suppression (IS) and response inhibition (RI) in children with ADHD. We also assessed the brain functions affected by the methylphenidate (MPH) effect by comparing the blood-oxygen level dependent (BOLD) signals in ADHD children on and off medication.
Methods: Eight children (9-11 years of age) with combined-type ADHD underwent rapid event-related functional magnetic resonance imaging (fMRI) during performance of a modified flanker task. Two fMRI (3.0 T) scans were conducted with a one week interval-one with MPH treatment and the other without. Functional maps were generated through group averaging and performance-based correlational analyses.
Results: Performances of the two cognitive control operations did not differ significantly between on-MPH and off-MPH status other than the reaction time to incongruent stimuli in ADHD children. In those affected by MPH treatment, an increased activation in the right prefrontal cortex during incongruent task was observed relative to a neutral trial in children with ADHD.
Conclusion: On the treatment of MPH, the ADHD children exhibited increased activation of the right frontal cortex during interference suppression. This finding suggested that MPH affected the right frontal cortex in ADHD compensating for a reduced level of interference suppression. Future studies will be required to ascertain the MPH effect of cognitive brain regions among large number of children with ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
American Psychiatric Association / 1994 / Task Force on D-I. Diagnostic and statistical manual of mental disorders: DSM-IV / American Psychiatric Association
Aron AR / 2005 / The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1285 ~ 1
Barkley RA / 1991 / Attention-deficit hyperactivity disorder: A clinical workbook / Guilford Press
Bunge SA / 2002 / Immature frontal lobe contributions to cognitive control in children: evidence from fMRI / Neuron 33 : 301 ~ 311
Castellanos FX / 1994 / Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder / Am J Psychiatry 151 : 1791 ~ 1796
Aron AR / 2005 / The cognitive neuroscience of response inhibition: relevance for genetic research in attention-deficit/hyperactivity disorder / Biol Psychiatry 57 : 1285 ~ 1
Barkley RA / 1991 / Attention-deficit hyperactivity disorder: A clinical workbook / Guilford Press
Bunge SA / 2002 / Immature frontal lobe contributions to cognitive control in children: evidence from fMRI / Neuron 33 : 301 ~ 311
Castellanos FX / 1994 / Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder / Am J Psychiatry 151 : 1791 ~ 1796
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