지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives：It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of
brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on
left and right temporoparietal cortex in schizophrenic patients with treatment-resistant auditory hallucination.
Methods：Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly allocated
to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20
international system at 1 Hz for 20 minutes per day for 10 treatment days. A Figure of eight TMS coil with a solid core was used
for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS),
Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment.
Results：Ten days administration of 1-Hz rTMS to temporoparietal cortex significant improved frequency (p<0.001) and
attentional salience (p=0.038) of auditory hallucination, positive (p<0.001) and negative symptom (p=0.02), and CGI-improvement
(p<0.001). There were no significant differences between right and left side stimulations.
Conclusion：These results suggest that the low frequency rTMS on temporoparietal cortex may be useful in treating schizophrenic
patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option. (J Korean
Neuropsychiatr Assoc 2004;43(5):546-551)
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
/ 1991 / Transcranial stimulation of motorcortexin upper motor neuron syndrome:its relation to motor deficit 81 : 377 ~ 388
/ 1993 / Increased blood flow inBroca’s area during auditory hallucinations in schizophrenia 342 : 703 ~ 706
/ 1993 / Left superiortemporal blood flow increases in schizophrenic and schizophreniformpatients with auditory hallucination:a longitudinal case study using123I-IMP SPECT 2
/ 1994 / Akinesia in parkinson’s disease I:shortening of simplereaction times with focal,single-pulse transcranial magnetic stimulation 44 : 884 ~ 891
/ 1994 / Responsesto rapid-rate transcranial magnetic stimulation of the human motorcortex 117 : 847 ~ 858
/ 1993 / Increased blood flow inBroca’s area during auditory hallucinations in schizophrenia 342 : 703 ~ 706
/ 1993 / Left superiortemporal blood flow increases in schizophrenic and schizophreniformpatients with auditory hallucination:a longitudinal case study using123I-IMP SPECT 2
/ 1994 / Akinesia in parkinson’s disease I:shortening of simplereaction times with focal,single-pulse transcranial magnetic stimulation 44 : 884 ~ 891
/ 1994 / Responsesto rapid-rate transcranial magnetic stimulation of the human motorcortex 117 : 847 ~ 858
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