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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 120 - 125 (6page)
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초록· 키워드
오류제보하기
The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms.
SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent
deacetylase silent information regulator 2 (known as Sir2), which is the best-characterized
SIRT family member. It regulates longevity in several model organisms and is involved
in several processes in mammalian cells including cell survival, differentiation, and metabolism.
SIRT1 induction, either by SIRT-activating compounds such as resveratrol, or metabolic
conditioning associated with caloric restriction, could have neuroprotective qualities and thus
delay the neurodegenerative process, thereby promoting longevity. However, the precise mechanistic
liaison between the activation of SIRT and extended healthy aging or delaying agerelated
diseases in humans has yet to be established.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Brunet A / 2004 / Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase / Science 303 : 2011 ~ 2015
Cheng HL / 2003 / Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice / Proc Natl Acad Sci U S A : 10794 ~ 10799
Daitoku H / 2004 / Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity / Proc Natl Acad Sci U S A : 10042 ~ 10047
Dryden SC / 2003 / Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle / Mol Cell Biol 23 : 3173 ~ 3185
Frye RA / 1999 / Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltrans
Cheng HL / 2003 / Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice / Proc Natl Acad Sci U S A : 10794 ~ 10799
Daitoku H / 2004 / Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity / Proc Natl Acad Sci U S A : 10042 ~ 10047
Dryden SC / 2003 / Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle / Mol Cell Biol 23 : 3173 ~ 3185
Frye RA / 1999 / Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltrans
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