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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 139 - 147 (9page)
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초록· 키워드
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Stroke is associated with high disability and mortality burdens worldwide, but there are few effective
and widely available therapies. There is therefore a need to develop treatments that promote
the repair and regeneration of ischemic brain tissue. In this regard, a population of adult
stem cells-called endothelial progenitor cells (EPCs)-has been identified in peripheral blood
that could provide novel approaches in regenerative medicine for curing patients with acute
ischemic stroke. There is accumulating evidence that EPCs can repair damaged endothelia and
attenuate the development and progression of atherosclerosis. Also, EPCs can be recruited in
response to acute ischemic events and participate in reparative vasculogenesis. Most studies
related to EPCs have involved patients with cardiovascular diseases, and there is emerging evidence
that EPCs represent a risk marker and a potential therapeutic agent in cerebrovascular
disease. Here we review the characteristics and biology of EPCs in cerebrovascular disease and
discuss the challenges that must be addressed to clarify the role and therapeutic applicability of
EPCs in cerebrovascular disease.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Asahara T / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275 : 964 ~ 967
Asahara T / 1999 / VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells / EMBO J 18 : 3964 ~ 3972
Brazelton TR / 2000 / From marrow to brain: expression of neuronal phenotypes in adult mice / Science 290 : 1775 ~ 1779
Chu K / 2008 / Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke / Stroke 39 : 1441 ~ 1447
Fadini GP / 2005 / Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus / J Am Coll Cardiol 45 : 1449 ~ 1457
Asahara T / 1999 / VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells / EMBO J 18 : 3964 ~ 3972
Brazelton TR / 2000 / From marrow to brain: expression of neuronal phenotypes in adult mice / Science 290 : 1775 ~ 1779
Chu K / 2008 / Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke / Stroke 39 : 1441 ~ 1447
Fadini GP / 2005 / Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus / J Am Coll Cardiol 45 : 1449 ~ 1457
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