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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 31 - 37 (7page)
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초록· 키워드
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Background and Purpose: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients.
Methods: This retrospective study investigated 60 epilepsy patients undergoing neuropsychological tests who were either newly diagnosed or untreated in the preceding 6 months. The cognitive function in 30 patients receiving LTG monotherapy and 30 age-matched patients receiving OXC monotherapy was compared after 1 year. The neuropsychological scores at baseline and all of the epilepsy-relevant variables except seizure type did not differ between the groups. The mean daily dosages of LTG and OXC at 1 year were 93 mg and 825 mg, respectively.
Results: The posttreatment list-learning performance was better in the LTG group than in the OXC group (p<0.05). The incidence of cognitive complaints did not differ between the two groups. The list-learning performance and Trail Making Test scores were better in each group after treatment.
Conclusions: LTG and OXC monotherapies have similar, slightly beneficial effects on cognitive function, and are probably not harmful.
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참고문헌 (26)
참고문헌 신청
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Bes A / 189-192. / Geraud G. Pharmacological exploration of dopamine hypersensitivity in migraine patients. Int J Clin Pharmacol Res 1986
Cerbo R / 1997 / Dopamine hypersensitivity in migraine: role of the apomorphine test 20 : 36 ~ 41
Daniels JK / 1996 / No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity 153 : 268 ~ 27
David J / / Rascol A. Does the piribedil test permit predicting the efficacy of domperidone in the treatment of migraine? Headache 1985 : 332 ~ 333
Bes A / 189-192. / Geraud G. Pharmacological exploration of dopamine hypersensitivity in migraine patients. Int J Clin Pharmacol Res 1986
Cerbo R / 1997 / Dopamine hypersensitivity in migraine: role of the apomorphine test 20 : 36 ~ 41
Daniels JK / 1996 / No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity 153 : 268 ~ 27
David J / / Rascol A. Does the piribedil test permit predicting the efficacy of domperidone in the treatment of migraine? Headache 1985 : 332 ~ 333
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