지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 174 - 179 (6page)
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초록· 키워드
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Objective Lamotrigine is a widely used medication for psychiatric disorders and epilepsy, but the adverse effects of this drug in adolescent Korean patients have not yet been investigated. In the present study, we sought to compare the incidence and impact of lamotrigine-induced skin rashes and different pattern of adverse events in psychiatric and nonpsychiatric adolescent patients.
MethodsaaUsing a retrospective cohort design, all of the charts were reviewed for adolescents (13 to 20 years old), treated with lamotrigine during the previous 2 years in the Child and Adolescent Psychiatric Clinic and Pediatric Neurologic Clinic of the Ulsan University Hospital in South Korea.
Results Of the 102 subjects, 23 patients developed a skin rash. All of these rashes were observed within 7 weeks of the initiation of the lamotrigine therapy. Only one subject developed a serious rash, which was diagnosed as Stevens-Johnson syndrome. Although the psychiatric subjects were administered statistically lower doses of lamotrigine during weeks 1 through 5 and at week 12, the likelihood of developing a rash was not significantly different between the psychiatric and nonpsychiatric patients.
Conclusion Careful dose escalation and close observation of side effects for the first 7 weeks of treatment is important. The present study reveals the tolerability of lamotrigine in an adolescent population, although a double-blind, controlled trial is needed to confirm these findings.
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참고문헌 (26)
참고문헌 신청
Alvestad S. / 2007 / Rash from antiepileptic drugs: influence by gender, age, and learning disability / Epilepsia 48 : 1360 ~ 1365
Bhangoo RK. / 2003 / Medication use in children and adolescents treated in the community for bipolar disorder / J Child Adolesc Psychopharmacol 13 : 515 ~ 522
Biederman J. / 2010 / A prospective open-label trial of lamotrigine monotherapy in children and adolescents with bipolar disorder / CNS Neurosci Ther 16 : 91 ~ 102
Brodie MJ. / 1999 / Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy / Epilepsy Res 3
Caranasos GJ. / 1974 / Drug-induced illness leading to hospitalization / JAMA 228 : 713 ~ 717
Bhangoo RK. / 2003 / Medication use in children and adolescents treated in the community for bipolar disorder / J Child Adolesc Psychopharmacol 13 : 515 ~ 522
Biederman J. / 2010 / A prospective open-label trial of lamotrigine monotherapy in children and adolescents with bipolar disorder / CNS Neurosci Ther 16 : 91 ~ 102
Brodie MJ. / 1999 / Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy / Epilepsy Res 3
Caranasos GJ. / 1974 / Drug-induced illness leading to hospitalization / JAMA 228 : 713 ~ 717
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