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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제3호
- 발행연도
- 2015.1
- 수록면
- 180 - 186 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: There have been several studies on comparisons of efficacy between subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in children with house dust mite (HDM)-sensitized allergic rhinitis (AR), without consistent results. This study was conducted to compare short-term effects between SCIT and SLIT in Korean children with HDM-sensitized AR.
Methods: Fifty-three children (mean age, 11.15±2.82 years) with HDM-sensitized AR and with/without asthma (SCIT group, n=33; SLIT group, n=20) were enrolled. Clinical symptom scores and skin prick test results were assessed before, and after 3, 6, and 12 months of immunotherapy. Blood tests, including eosinophils, total serum IgE, and HDM-specific IgE, and adenosine 5’-monophosphate, and methacholine bronchial challenge tests were performed before and after 12 months of immunotherapy.
Results: In the SCIT group, the symptom scores improved after 3 months compared to those before immunotherapy, whereas they improved after 6 months in the SLIT group. Significant decreases in skin reactivity to HDM were observed after 3 months only in the SCIT group. Decreases in total eosinophil counts and improvements in methacholine bronchial provocation tests were observed after 12 months of immunotherapy only in the SCIT group. No difference in severe adverse reactions was noted in either group.
Conclusion: The results of this study suggest that SCIT may have more rapid effects on clinical symptoms and skin reactivity in children with AR, compared to SLIT.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Bodtger U / 2002 / The safety and efficacy of subcutaneous birch pollen immunotherapy: a one-year, randomised, double-blind, placebo-controlled study / Allergy 57 : 297 ~ 30
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Di
Custovic A / 2005 / The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma : ARIA update(in collaboration with GA(2)L
Eifan AO / 2010 / Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite :
Eifan AO / 2013 / Allergen immunotherapy for house dust mite : clinical efficacy and immunological mechanisms in allergic rhinitis and asthma / Expert Opin Biol Ther 13 : 154
Crapo RO / 2000 / Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Di
Custovic A / 2005 / The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma : ARIA update(in collaboration with GA(2)L
Eifan AO / 2010 / Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite :
Eifan AO / 2013 / Allergen immunotherapy for house dust mite : clinical efficacy and immunological mechanisms in allergic rhinitis and asthma / Expert Opin Biol Ther 13 : 154
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