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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제1호
- 발행연도
- 2015.1
- 수록면
- 30 - 36 (7page)
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초록· 키워드
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Background: Pancreatic neuroendocrine tumors (PanNETs) are malignant endocrine neoplasms that present diverse clinical behaviors. Therefore, identification of biomarkers of PanNETs is important for stratification of the prognosis of PanNET patients. Recently, cytokeratin 19 (CK19) and KIT expression were reported to have prognostic significance in PanNET patients. Methods: To identify their prognostic significance, CK19 and KIT protein expression were assessed in 182 surgically resected PanNETs and compared with clinicopathologic factors. Results: Of 182 PanNETs cases, CK19 and KIT expression was noted in 97 (53.3%) and 16 (8.8%) cases, respectively. PanNET patients with CK19 expression had larger tumors (p=.006), higher World Health Organization (WHO) grade (p=.002) and pT classification (p<.001), increased distant metastasis (p=.004), and lymphovascular (p=.012) and perineural (p=.019) invasion. Similarly, those with KIT expression had larger tumors (p=.030), higher WHO grade (p=.001), advanced pT classification (p<.001), distant metastasis (p=.001), and lymphovascular invasion (p=.014). The 5-year survival rate for PanNET patients with KIT expression was significantly lower (62%) than that of patients without KIT expression (77%, p=.011), as determined by univariate but not by multivariate analyses. Conclusions: CK19 and KIT expression correlate with higher metastatic potential and advanced disease stage, and KIT expression is associated with worse survival in PanNET patients.
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참고문헌 (31)
참고문헌 신청
Hong SM / 2007 / Clinical and prognostic significances of nuclear and cytoplasmic KIT expressions in extrahepatic bile duct carcinomas / Mod Pathol 20:562~569
Scobie JV / 2003 / C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance / Int J Gynecol Pathol 22:149~155
Chung CY / 2005 / Expression of c-kit protooncogene in human hepatocellular carcinoma / Cancer Lett 217:231~236
Krams M / 2004 / Expression of the c-kit receptor characterizes a subset of neuroblastomas with favorable prognosis / Oncogene 23:588~595
Piper K / 2004 / Beta cell differentiation during early human pancreas development / J Endocrinol 181:11~23
Scobie JV / 2003 / C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance / Int J Gynecol Pathol 22:149~155
Chung CY / 2005 / Expression of c-kit protooncogene in human hepatocellular carcinoma / Cancer Lett 217:231~236
Krams M / 2004 / Expression of the c-kit receptor characterizes a subset of neuroblastomas with favorable prognosis / Oncogene 23:588~595
Piper K / 2004 / Beta cell differentiation during early human pancreas development / J Endocrinol 181:11~23
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