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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제2호
- 발행연도
- 2020.1
- 수록면
- 184 - 187 (4page)
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초록· 키워드
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A 39-year-old man visited the department of otolaryngology due to an ongoing hearing disturbance that had lasted for 1 year. Temporal bone computed tomography revealed soft tissue density nearly obliterating the left external auditory canal (EAC). The mass was composed of sheets of round tumor cells containing moderate amounts of fine granular cytoplasm and salt and pepper chromatin. Neither mitosis nor necrosis was found. The Ki-67 proliferation index was less than 2%. Cells were positive for CD56 and synaptophysin but negative for chromogranin, cytokeratin (CK) 20, and CK7. Based on these findings, the tumor was diagnosed as a carcinoid tumor, well differentiated neuroendocrine carcinoma, grade 1 (G1) according to current World Health Organization (WHO) classification of head and neck tumors; and a neuroendocrine tumor, G1 according to neuroendocrine neoplasm (NEN)-2018 WHO standard classification. He remained free of local recurrence and metastasis after 20 months of follow up. To date, only six cases of primary NENs in the EAC have been reported. Metastatic tumor should be included in the differential diagnoses. Because of its rarity, the prognosis and treatment have not yet been clarified.
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참고문헌 (13)
참고문헌 신청
Pelosi S / 2015 / Adenomatous tumors of the middle ear / Otolaryngol Clin North Am 48:305~315
Manipoud P / 1994 / Cutaneous neuroendocrine carcinoma of the external ear canal / Ann Otolaryngol Chir Cervicofac 111:111~114
Litofsky NS / 1998 / Merkel cell carcinoma of the external auditory canal invading the intracranial compartment / Am J Otolaryngol 19:330~334
Mahalingam M / 2006 / Cutaneous neuroendocrine adenoma : an uncommon neoplasm / J Cutan Pathol 33:315~317
Palma S / 2007 / Merkel cell tumour of the external ear : report of a case / Auris Nasus Larynx 34:229~232
Manipoud P / 1994 / Cutaneous neuroendocrine carcinoma of the external ear canal / Ann Otolaryngol Chir Cervicofac 111:111~114
Litofsky NS / 1998 / Merkel cell carcinoma of the external auditory canal invading the intracranial compartment / Am J Otolaryngol 19:330~334
Mahalingam M / 2006 / Cutaneous neuroendocrine adenoma : an uncommon neoplasm / J Cutan Pathol 33:315~317
Palma S / 2007 / Merkel cell tumour of the external ear : report of a case / Auris Nasus Larynx 34:229~232
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