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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제36권 제2호
- 발행연도
- 2002.1
- 수록면
- 84 - 92 (9page)
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In unilateral ureteral obstruction (UUO), the obstructed kidney is characterized by interstitial fibrosis and an increase in transforming growth factor (TGF)-β1. Interstitial expression of TGF-β1 is important in tublointerstitial fibrosis. The objectives of this study is to make new ribbon-type antisense oligodeoxynucleotides (ODN) for TGF-β1 which are resistant to exonuclease and to examine the effects of TGF-β1 on reducing tubulointerstitial fibrosis of the kidney. Methods : We introduced a new ribbon-type antisense ODN for TGF-β1 in rats
using the UUO model to block interstitial fibrosis by tail vein injection. A combination of one
antisense sequences for TGF-β1 was adopted to construct a large antisense molecule with a loop and stem. Artificial viral envelope (AVE)-type hemagglutinating virus of Japan (HVJ)- liposomes were used as a vector system for the delivery of antisense ODN. Results : The
levels of TGF-β1 mRNA was decreased more in the cultured mesangial cells treated with ribbon-type antisense ODN than in that of a linear-type antisense ODN for TGF-β1. TGF-β1 mRNA was increased markedly in the interstitium of untreated obstructed kidneys. Northern analysis revealed that the levels of TGF-β1 mRNA were decreased in the obstructed kidneys
treated with antisense ODN. The fibrosis of the obstructed kidneys treated with ribbon-type antisense ODN was dramatically less than that of the untreated group. Conclusions : These results demonstrate that the introduction of new ribbon-type antisense ODN for TGF-β1 may be a potential therapeutic maneuver for preventing interstitial fibrosis.
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