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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제3호
- 발행연도
- 2007.1
- 수록면
- 139 - 148 (10page)
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Background : Mucin phenotypic markers and CDX2 are widely expressed in gastric carcinomas,
however, recent studies have produced conflicting results regarding whether the expression
patterns of these markers have clinicopathologic significance. Methods : We examined
samples from 217 gastric carcinoma patients immunohistochemically to determine if the expression
of mucin phenotypic markers and CDX2 was correlated with postoperative survival and
other clinicopathologic factors. Results : All tumors were phenotypically classified as gastric
(type G, 81 cases), gastric and intestinal mixed (type GI, 55 cases), intestinal (type I, 43 cases),
or unclassified (type U, 38 cases). The occurrence of type G and GI tumors was positively correlated
with tumor progression whereas that of type U tumors was negatively correlated with
tumor progression. CDX2 expression was correlated with type I tumors. Tumors that expressed
MUC5AC or MUC6 had a better prognosis than those that did not. When the relationship between
phenotype and prognosis was considered, type GI had the best prognosis, followed by
type G, then type U. Conclusions : The mucin phenotypic markers may be useful for predicting
tumor progression and survival in patients with gastric carcinomas. Additionally, CDX2 may
play an important role in gastric carcinogenesis of type I tumors.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ 1997 / Intestinalization of gastric signet ring cell carcinomas with progression 431 : 103 ~ 110
/ 1998 / Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression 1 : 134 ~ 141
/ 2000 / Distinction of differentiated type early gastric carcinoma with gastric type mucin expression 89 : 724 ~ 732
/ 2000 / Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma 113 : 374 ~ 382
/ 2001 / Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions 61 : 212 ~ 220
/ 1998 / Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression 1 : 134 ~ 141
/ 2000 / Distinction of differentiated type early gastric carcinoma with gastric type mucin expression 89 : 724 ~ 732
/ 2000 / Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma 113 : 374 ~ 382
/ 2001 / Gastric and intestinal phenotypic marker expression in gastric carcinomas and its prognostic significance: immunohistochemical analysis of 136 lesions 61 : 212 ~ 220
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