Expression of CDX2 and Villin in Gastric Cardiac Intestinal Metaplasia and the Relation with Gastric Cardiac Carcinogenesis

Xiao, Zhong-Yue; Ru, Yi; Sun, Jiang-Tao; Gao, She-Gan; Wang, Yu-Feng; Wang, Li-Dong; Feng, Xiao-Shan

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저자정보: Xiao, Zhong-Yue (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology) Ru, Yi (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology) Sun, Jiang-Tao (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology) Gao, She-Gan (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology) Wang, Yu-Feng (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology) Wang, Li-Dong (Henan Key Laboratory for Esophageal Cancer Research, College of Medicine, Zhengzhou University) Feng, Xiao-Shan (Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Science and Technology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제1호

발행연도: 2012.1

수록면: 247 - 250 (4page)

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Objective: To determine whether CDX2 and villin protein expression are associated with intestinal metaplasia (IM) in gastric cardiac mucosa and to explore the relationship with evolution of gastric cardiac adenocarcinoma (GCA). Methods: We studied 143 gastric cardiac biopsy or resection specimens from Henan province China, including 25 cardiac gastritis specimens with IM, 65 dysplasia specimens with IM and 35 gastric cardiac adenocarcinoma specimens and stained them for CDX2 and villin by the immunohistochemical SP method. 15 normal gastric cardiac biopsy specimens were also collected as control. Results: (1) Normal gastric mucosa presented no CDX2 and villin expression. The positive rates of CDX2 protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 84.0% (21/25), 66.7% (32/48) and 36.4% (20/55), respectively. While the positive rates of villin protein in cardiac gastritis with IM, dysplasia with IM, and carcinoma tissues were 76.0% (19/25), 70.8% (34/48) and 45.5% (25/55), respectively. There were significant differences among the three groups for both CDX2 and villin (P<0.01). Spearman's rank correlation coefficient(rho) showed a close correlation between the two proteins (r=0.843, P<0.01) and both were positively related with tumor differentiation (both P<0.05), but not associated with age, sex, invasion and metastasis of lymph node (P>0.05). Conclusion: Our results suggest that ectopic expression of CDX2 and villin may be involved in early-stage IM and tumorigenesis in gastric cardia and the expression of villin may be regulated by CDX2.

#CDX2 #villin #gastric cardiac #intestinal metaplasia #adenocarcinoma #protein expression

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Xiao, Zhong-Yue

소속기관 Department of Oncology, Cancer Institute, the First Affiliated Hospital of Henan University of Scien