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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제5호
- 발행연도
- 2007.1
- 수록면
- 316 - 323 (8page)
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초록· 키워드
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An association between the epidermal growth factor receptor (EGFR) signaling
pathway and the response of cancer cells to ionizing radiation has been previously described.
Preoperative radiochemotherapy (PRCT) has been administered for treating locally
advanced rectal cancer to improve the outcomes, and to preserve the sphincter from lowlying
tumor. However, the responses of tumors to PRCT are variable and there are currently
no reliable markers that predict the therapeutic benefits. We studied the association between
EGFR overexpression and the tumor response to PRCT in rectal cancer. Methods : The
EGFR protein expression, as determined by immunohistochemistry, was analyzed in the
pretreatment biopsy specimens from 120 patients with advanced rectal cancer. The tumor
response was graded in the surgically resected specimens by using a three-scale grading
system: no response (NR), partial remission (PR) and complete remission (CR). Results :
NR was identified in 70 cases (58.3%). Fifty patients (41.7%) responded to PRCT; 27 (22.5%)
achieved a PR and 23 (19.2%) achieved a CR. EGFR overexpression was detected in 78
(65%) cases. Seventy-eight percent (39/50) of the tumors with a CR/PR revealed EGFR reactivity,
whereas 55.7% (39/70) of the tumors with NR showed an EGFR expression (p=0.048).
Conclusions : The EGFR protein expression might be a valuable marker for identifying those
patients who are most likely to benefit from PRCT.
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참고문헌 (25)
참고문헌 신청
/ / Fuks Z. Effect of epidermalgrowth factor on the growth and radiation sensitivity of humanbreast cancer cells in vitro. Int J Radiat Oncol Biol Phys 1994 : 91 ~ 8
/ / Marks G. Downstagingof advanced rectal cancer following combined preoperativechemotherapy and high dose radiation. Int J Radiat Oncol BiolPhys 1994 : 169 ~ 75
/ / Ridge JA. Radi
/ / Sutherland RM. Differences in EGF related radiosensitisationof human squamous carcinoma cells with high and low numbersof EGF receptors. Br J Cancer 1991 : 251 ~ 4
/ / et al. Expression of cell cycle-regulatoryproteins in rectal cancer significance of the tumor response to preoperativeradiochemotherapy and for the prognosis. Korean J Pa
/ / Marks G. Downstagingof advanced rectal cancer following combined preoperativechemotherapy and high dose radiation. Int J Radiat Oncol BiolPhys 1994 : 169 ~ 75
/ / Ridge JA. Radi
/ / Sutherland RM. Differences in EGF related radiosensitisationof human squamous carcinoma cells with high and low numbersof EGF receptors. Br J Cancer 1991 : 251 ~ 4
/ / et al. Expression of cell cycle-regulatoryproteins in rectal cancer significance of the tumor response to preoperativeradiochemotherapy and for the prognosis. Korean J Pa
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