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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 228 - 235 (8page)
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Purpose: The epidermal growth factor receptor (EGFR) family plays a crucial role in the growth of malignant tumors. EGFR and human EGFR 2 (HER2) protein overexpression are associated with an unfavorable prognosis and are important therapeutic targets in breast cancer. The aim of this study was to evaluate the relationship between EGFR and HER2 expression and clinicopathological factors in papillary thyroid carcinoma (PTC) at a single institution. Methods: A total of 129 consecutive patients with PTC were enrolled in this study and underwent thyroid surgery between October 2013 and February 2015. EGFR and HER2 protein expression was evaluated in the 129 primary tumors by immunohistochemistry, and the results were compared with the clinicopathological features. Results: Of the 129 PTC tumors, 20 (15.5%) were HER2 positive, and 109 (84.5%) were HER2 negative. Moreover, EGFR positivity were observed in 111 (86%) tumors. The mean age of the patients was 46.3±11.9 years (range, 20–74 years), and the mean tumor size was 1.08±0.75 cm (range, 0.2–3.5 cm). Tumor size, extrathyroidal extension, histological subtype, and TNM stage were not significantly associated with EGFR or HER2 expression. Meanwhile, high Ki-67 labeling index was significantly associated with EGFR expression (P=0.002), HER2 expression was significantly associated with younger age (≤45 years) and cervical lymph node metastasis. Conclusion: Based on our data, it is not clear whether EGFR and HER2 expression is associated with tumor aggressiveness in PTC.
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참고문헌 (29)
참고문헌 신청
Davies L / 2006 / Increasing incidence of thyroid cancer in the United States, 1973–2002 / JAMA 295:2164~2167
Pellegriti G / 2013 / Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors / J Cancer Epidemiol 2013:965212
Kim YS / 2012 / Clinical predictors of right upper paraesophageal lymph node metastasis from papillary thyroid carcinoma / World J Surg Oncol 10:164
Tang KT / 2010 / BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications / J Chin Med Assoc 73:113~128
Sipos JA / 2010 / Thyroid cancer epidemiology and prognostic variables / Clin Oncol (R Coll Radiol) 22:395~404
Pellegriti G / 2013 / Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors / J Cancer Epidemiol 2013:965212
Kim YS / 2012 / Clinical predictors of right upper paraesophageal lymph node metastasis from papillary thyroid carcinoma / World J Surg Oncol 10:164
Tang KT / 2010 / BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications / J Chin Med Assoc 73:113~128
Sipos JA / 2010 / Thyroid cancer epidemiology and prognostic variables / Clin Oncol (R Coll Radiol) 22:395~404
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