지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제6호
- 발행연도
- 2009.1
- 수록면
- 575 - 579 (5page)
이용수
초록· 키워드
오류제보하기
A 40-year-old man with chronic hepatitis B complained of progressive weakness of the proximal muscles and edema of both legs. He had been receiving long-term clevudine (nucleoside analogue reverse transcriptase inhibitor, NRTI) therapy for his hepatitis. The serum creatine
kinase level was increased on the laboratory tests. His electromyography showed a generalized myopathic process. The muscle biopsy showed numerous ragged-red fibers, degenerating myofibers with variable sized cytoplasmic bodies, the prominence of type 1 fibers with type 2 fiber atrophy and an endomysial mononuclear cell infiltration. The electron microscopic
examination revealed necrotic myofibers, including extremely dysmorphic mitochondria with extensive loss, blunting and focal clumping of the cristae and concentric cristae. Although clevudine is known to be a less cytotoxic agent among the various NRTIs, careful clinical attention
should be paid to the patients who are receiving long-term clevudine therapy for the occurrence of myopathy.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Asselah T / 2008 / Clevudine: a promising therapy for the treatment of chronic hepatitis B / Expert Opin Investig Drugs 17 : 1963 ~ 1974
Authier FJ / 2005 / Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HARRT) / Muscle Ne
Balakrishna Pai S / 1996 / Inhibition of hepatitis B virus by a novel L-nucleoside, 2′-fluoro-5-methyl-beta-L-arabinofuranosyl uracil / Antimicrob Agents Chemother 40 : 380
Bayrakci US / 2008 / Renal fanconi syndrome and myopathy after liver transplantation:drug-related mitochondrial cytopathy? / Pediatr Transplant 12 : 109 ~ 112
Carr A / 2000 / Adverse effects of antiretroviral therapy / Lancet 356 : 1423 ~ 1430
Authier FJ / 2005 / Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HARRT) / Muscle Ne
Balakrishna Pai S / 1996 / Inhibition of hepatitis B virus by a novel L-nucleoside, 2′-fluoro-5-methyl-beta-L-arabinofuranosyl uracil / Antimicrob Agents Chemother 40 : 380
Bayrakci US / 2008 / Renal fanconi syndrome and myopathy after liver transplantation:drug-related mitochondrial cytopathy? / Pediatr Transplant 12 : 109 ~ 112
Carr A / 2000 / Adverse effects of antiretroviral therapy / Lancet 356 : 1423 ~ 1430
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