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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 40 - 45 (6page)
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초록· 키워드
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Background: Telbivudine is a nucleoside analogue used for the treatment of chronic hepatitis B, but it often develops mitochondrial toxicity leading to symptomatic myopathy. In this study, three patients with telbivudine induced myopathy were enrolled in order to investigate the nature and pathogenesis of mitochondrial toxicity caused by long-term use of telbivudine.
Methods: Clinical features, laboratory findings, muscle pathology, and quantitation of mitochondrial DNA were studied in three patients.
Results: Patients presented with progressive muscle weakness with high serum creatine kinase levels. Light microscopic findings of muscle pathology showed ragged red fibers that reacted strongly with succinate dehydrogenase stain, but negative for cytochrome c oxidase activities. Electron microscopy revealed abnormal mitochondrial accumulation with rod shaped inclusions. The quantitative peroxidase chain reaction showed a depletion of mitochondrial DNA in skeletal muscle of the patients.
Conclusions: Nucleoside analogues including telbivudine are potent inhibitors of viral DNA polymerases. However, they are not specific for viral DNA and can disturb mitochondrial replication at the same time. All nucleotide analogues should be used with close clinical observation in order to avoid development of mitochondrial myopathy.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Ambang T / 2016 / Clinicopathological features of telbivudine-associated myopathy / PLoS ONE 11 : e0162760 ~
Dalakas MC / 1990 / Mitochondrial myopathy caused by long-term zidovudine therapy / N Engl J Med 322 : 1098 ~ 1105
Eun Hye Kim / 2013 / Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B / Clinical and Molecular Hepatology 19 (1) : 82 ~ 86
Fattovich G / 2008 / Natural history of chronic hepatitis B : special emphasis on disease progression and prognostic factors / J Hepatol 48 : 335 ~ 352
Liaw YF / 2009 / 2-year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B / Gastroenterology 136 : 486 ~ 495
Dalakas MC / 1990 / Mitochondrial myopathy caused by long-term zidovudine therapy / N Engl J Med 322 : 1098 ~ 1105
Eun Hye Kim / 2013 / Two cases of telbivudine-induced myopathy in siblings with chronic hepatitis B / Clinical and Molecular Hepatology 19 (1) : 82 ~ 86
Fattovich G / 2008 / Natural history of chronic hepatitis B : special emphasis on disease progression and prognostic factors / J Hepatol 48 : 335 ~ 352
Liaw YF / 2009 / 2-year GLOBE trial results: telbivudine is superior to lamivudine in patients with chronic hepatitis B / Gastroenterology 136 : 486 ~ 495
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