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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제1호
- 발행연도
- 2004.1
- 수록면
- 42 - 45 (4page)
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초록· 키워드
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Background : RUNX3 is expressed throughout the luminal gastrointestinal tract. RUNX3 is
on chromosome 1p36, a location considered to carry an important tumor suppressor for many
types of cancers. Epigenetic silencing of RUNX3 is causally related to human gastric cancer.
Methods : Colorectal cancers, adenoma, and the corresponding normal mucosa were obtained
from 26 individual patients. To identify methylation of RUNX3 in colonic carcinogenesis, methylation-
specific PCR was performed. Results : RUNX3 methylation was found in one case of
colonic carcinoma. The normal mucosa and tubular adenoma of this case had no methylation.
No other cases were found to have methylations. Conclusions : These results are very
different from the findings of gastric carcinomas, where frequent DNA methylation in the vicinity
of the RUNX3 promoter is found. Although, the possibility of a role of RUNX3 methylation in
the colon can not be completely ruled out, these results suggest that methylation of the RUNX3
promoter region might not contribute to the adenoma-carcinoma sequence of the colon.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1994 / the human members of the runt domaingene-family: cDNA structure, expression, and chromosomal localization 23 : 425 ~ 432
/ 1995 / Cloning, mapping and expressionof PEBP2 alpha C, a third gene encoding the mammalian Runtdomain. 159 : 245 ~ 248
/ 1995 / Inactivation of the type II TGFbetareceptor in colon cancer cells with microsatellite instability 268 : 1336 ~ 1338
/ 1995 / Mapping of the mousehomolog of the human runt domain gene,AML2, to the distal regionof mouse chromosome 4 25 : 603 ~ 605
/ 1995 / Microsatellite instability and mutationsof the transforming growth factor beta type II receptor gene incolorectal cancer 55 : 5548 ~ 5550
/ 1995 / Cloning, mapping and expressionof PEBP2 alpha C, a third gene encoding the mammalian Runtdomain. 159 : 245 ~ 248
/ 1995 / Inactivation of the type II TGFbetareceptor in colon cancer cells with microsatellite instability 268 : 1336 ~ 1338
/ 1995 / Mapping of the mousehomolog of the human runt domain gene,AML2, to the distal regionof mouse chromosome 4 25 : 603 ~ 605
/ 1995 / Microsatellite instability and mutationsof the transforming growth factor beta type II receptor gene incolorectal cancer 55 : 5548 ~ 5550
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Methylation of the Tumor Suppressor Gene RUNX3 in Human Gastric Carcinoma
Gut and Liver
2008 .01
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Prognostic Significance of Methylation Profiles in Urothelial Carcinomas of the Bladder
Journal of Pathology and Translational Medicine
2010 .01
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c-kit 돌연변이가 동반된 RUNX1/RUNX1T1 양성 급성골수성백혈병에서의 골수육종
대한내과학회지
2011 .01
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골육종에서 RUNX3 CpG Island의 비정상적 과도 메틸화
대한정형외과학회지
2009 .06
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Expression pattern of Runx2 in murine tooth development
대한소아치과학회지
2004 .01
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Oxidative Stress Induces Hypomethylation of LINE-1 and Hypermethylation of the RUNX3 Promoter in a Bladder Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Epigenetic inactivation of RUNX3 in colorectal cancer
Annals of Surgical Treatment and Research
2018 .03
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위암에서 RUNX3 발현의 임상적 의의
대한외과학회 학술대회 초록집
2006 .11
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샘종암종연쇄를 동반한 대장암에서 Vimentin 유전자의 프로모터 메틸화에 관한 연구
Journal of Pathology and Translational Medicine
2010 .01
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Expression of RUNX3 Gene is Downregulated in Breast Cancer
대한외과학회 학술대회 초록집
2006 .05
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Increased Oxidative Stress and RUNX3 Hypermethylation in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma (HCC) and Induction of RUNX3 Hypermethylation by Reactive Oxygen Species in HCC Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Promoter Methylation and Relative mRNA Expression of the p16 Gene in Cervical Cancer in North Indians
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Overexpression of RUNX3 Inhibits Malignant Behaviour of Eca109 Cells in Vitro and Vivo
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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The first review study on association of DNA methylation with gastric cancer in Iranian population
Asian Pacific journal of cancer prevention : APJCP
2016 .01
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Quantitative analysis of COX-2 promoter methylation in gastric carcinoma
Annals of Surgical Treatment and Research
2018 .08
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t(8;21) 잠재 염색체 변화로 인해 RUNX1-RUNX1T1 재배열을 보인 근네배수체증 급성골수백혈병 1예
Annals of Laboratory Medicine
2009 .01
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The Relationship DNA Methylation of $p16^{INK4a}$ and Colorectal Cancer
Molecular & cellular toxicology
2007 .01
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위의 저등급 점막 관련 림프조직 림프종에서 Helicobacter pylori치료에 따른 p16메틸화의 변화
Journal of Pathology and Translational Medicine
2002 .01
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Disease Progression from Chronic Hepatitis C to Cirrhosis and Hepatocellular Carcinoma is Associated with Increasing DNA Promoter Methylation
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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