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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제6호
- 발행연도
- 2004.1
- 수록면
- 357 - 363 (7page)
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Background : Promyelocytic leukemia protein (PML) is a primary biliary cirrhosis (PBC)-specific autoantigen. Anti-PML antibody is analyzed using cultured cells with patient sera, however, PML expression has rarely been examined in liver tissues. Methods : In the present study, PML expression was examined immunohistochemically in paraffin embedded liver needle biopsy specimens obtained from 20 cases of PBC, 10 cases of autoimmune cholangitis, 36 cases of autoimmune hepatitis and from 5 cases of noninflammatory livers. Results : Variable PML immunopositivity was detected in the bile duct epithelial cells of 18 (90.0%) of 20 PBC cases and in all 10 cases (100.0%) of autoimmune cholangitis, whereas it was only present in 6 (16.7%) of 36 cases of autoimmune hepatitis (p<0.001). In contrast, hepatocyte PML immunopositivity was higher in autoimmune hepatitis (33/36 cases, 90.8%), than in PBC (10/20 cases, 50.0%) or autoimmune cholangitis (3/10 cases, 30.0%) (p<0.05). Conclusions : Our data indicate that the differential expression of PML is closely related to autoimmune liver diseases type, and suggest that the overexpression of PML protein in bile duct cells is associated with the development of autoantibodies in patients with PBC or autoimmune cholangitis. Furthermore, PML immunoreactivity may be useful for the diagnosis of autoimmune cholangitis and overlap syndrome.
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참고문헌 (28)
참고문헌 신청
/ / Nuclear antibodies in primarybiliary cirrhosis immu (logy and liver)
/ / a distinct syndrome of autoimmunecholangitis : 260 ~ 5
/ 1987;138 / Identification andspecificity of a cDNA encoding the 70kD mitochondrial antigen recognizedin primary biliary cirrhosis. : 3525 ~ 31
/ 1995 / Autoimmunecholangitis: a variant of primary biliary cirrhosis Clinicopathologicand serologic correlations in 200 cases, 40 : 1232 ~ 1242
/ 1995 / High prevalence of antibodiesto recombinant CENP-B in primary biliary cirrhosis:nuclear immunofluorescencepatterns and ELISA reactivities. 10 : 438 ~ 445
/ / a distinct syndrome of autoimmunecholangitis : 260 ~ 5
/ 1987;138 / Identification andspecificity of a cDNA encoding the 70kD mitochondrial antigen recognizedin primary biliary cirrhosis. : 3525 ~ 31
/ 1995 / Autoimmunecholangitis: a variant of primary biliary cirrhosis Clinicopathologicand serologic correlations in 200 cases, 40 : 1232 ~ 1242
/ 1995 / High prevalence of antibodiesto recombinant CENP-B in primary biliary cirrhosis:nuclear immunofluorescencepatterns and ELISA reactivities. 10 : 438 ~ 445
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