지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Drug-induced hepatotoxicity is injury to the liver as a result of drug exposure. Due to their unpredictable nature, drug-induced liver injuries pose a serious problem for clinicians, health agencies, and pharmaceutical firms. Albendazole is a benzimidazole with wide spectrum coverage as an antiparasitic drug. Very few cases of high-dose albendazole- induced hepatotoxicity have been reported so far, and no case in response to a single dose. A 25-year-old man presented to our hospital with dark urine. Twenty days prior to presentation, he took a tablet of albendazole (400 mg) as a prophylactic treatment for lumbricosis. Upon laboratory analysis, aspartate aminotransferase (AST) was 748 IU/L, alanine transaminase (ALT) was 939 IU/L, and total/direct bilirubin was 9.3/7.3 mg/dL. The patient was negative for viral markers (HAV, HBV, and HCV) and autoantibodies. Abdominal ultrasonography revealed no evidence of chronic liver damage. The pathology was compatible with drug-induced hepatotoxicity. The patient improved with conservative management only. (Korean J Med 75:564-568, 2008)
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Choudhuri G / 1988 / Jaundice due to albendazole / Indian J Gastroenterol 7 : 245 ~ 246
Danan G / 1993 / Causality assessment of adverse reactions to drugs:-I. a novel method based on the conclusions of international consensus meetings: application to drug-indu
Dilger K / 1997 / CYP2E1 activity in patients with alcoholic liver disease / J Hepatol 27 : 1009 ~ 1014
Farrell GC / 1994 / Drug-induced liver disease / Churchill Livingstone
Horton RJ / 1997 / Albendazole in treatment of human cystic echinococcosis: 12 years of experience / Acta Trop 64 : 79 ~ 93
Danan G / 1993 / Causality assessment of adverse reactions to drugs:-I. a novel method based on the conclusions of international consensus meetings: application to drug-indu
Dilger K / 1997 / CYP2E1 activity in patients with alcoholic liver disease / J Hepatol 27 : 1009 ~ 1014
Farrell GC / 1994 / Drug-induced liver disease / Churchill Livingstone
Horton RJ / 1997 / Albendazole in treatment of human cystic echinococcosis: 12 years of experience / Acta Trop 64 : 79 ~ 93
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