지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: There has been a lot of controversy about whether Korean traditional medicines cause drug-induced hepatotoxicity or not. However, this controversy has not been examined from a scientific approach, especially in terms of toxicology. Thus, this article for traditional Korean medicine-induced hepatotoxicity was reviewed on a basis of toxicological assessment.
Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide.
Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.
Methods: Toxicological assessments were carried out in a view of reactive intermediates formation from biotransformation in animals based on cytochrome P450 activity inducing oxidative stress, and case reports in world-wide.
Results and Conclusions: Several herbal materials used for traditional Korean medicines were identified as possible agents causing drug-induced hepatotoxicity. Most of these agents seem to produce toxic reactive intermediates caused by cytochrome P450. Oxidative stress followed by cytochrome P450 activation could also be a reason for herb-induced hepatotoxicity. Plausible prevention of herb-induced hepatotoxicity was suggested.
목차
서론
본론
요약 및 결론
감사의 글
참고문헌
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Eisenberg DM / 1998 / Trends in alternative medicine use in the United States, 1990-1997 / J Am Med Assoc 280 : 1569 ~ 1575
2. [단행본] - Stricker B / 1992 / Drug-induced Hepatic Injury / Elsevier : 25 ~ 35
3. [학술지(정기간행물)] - Jean-Pastor MJ / 1984 / des accidents htpatiques medicamenteux recueillis par la pharmacovigilance fransaise / Therapie 39 : 493 ~ 500
4. [학술지(정기간행물)] - Dossing M / 1982 / Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish board of adverse reaction to drugs / Stand J Gastroenter 17 : 205 ~ 511
5. [보고서] - 식품의약품안전청 / 2005 / 한약 간독성보고서 : 20 ~ 40
2. [단행본] - Stricker B / 1992 / Drug-induced Hepatic Injury / Elsevier : 25 ~ 35
3. [학술지(정기간행물)] - Jean-Pastor MJ / 1984 / des accidents htpatiques medicamenteux recueillis par la pharmacovigilance fransaise / Therapie 39 : 493 ~ 500
4. [학술지(정기간행물)] - Dossing M / 1982 / Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish board of adverse reaction to drugs / Stand J Gastroenter 17 : 205 ~ 511
5. [보고서] - 식품의약품안전청 / 2005 / 한약 간독성보고서 : 20 ~ 40
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UCI(KEPA) : I410-ECN-0101-2014-519-000281073