지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 131 - 136 (6page)
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Porphyromonas gingivalis is one of the most important periodontal pathogens and has been to known to invade various types of cells, including endothelial cells. The present study investigated the mechanisms involved in the internalization of P. gingivalis in human umbilical vein endothelial cells (HUVEC). P. gingivalis internalization was reduced by clathrin and lipid raft inhibitors, as well as a siRNA knockdown of caveolin-1, a principal molecule of lipid raft-related caveolae. The internalization was also reduced by perturbation of actin rearrangement, while microtubule polymerization was not required. Furthermore, we found that Src kinases are critical for the internalization of P. gingivalis into HUVEC, while neither Rho family GTPases nor phosphatidylinositol 3-kinase are required. Taken together, this study indicated that P. gingivalis internalization into endothelial cells involves clathrin and lipid rafts and requires actin rearrangement associated with Src kinase activation.
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참고문헌 (28)
참고문헌 신청
Abraham S / 2001 / Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis / J Infect Dis 183(Suppl 1):S51~55
Xue Q / 2010 / Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K / PLoS One 5:e11665
Agerer F / 2003 / Integrinmediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases / J Biol Chem 278:42524~42531
Chen L / 2006 / Roles of cortactin, an actin polymerization mediator, in cell endocytosis / Acta Biochim Biophys Sin 38:95~103
Abraham S / 2001 /
Xue Q / 2010 / Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K / PLoS One 5:e11665
Agerer F / 2003 / Integrinmediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases / J Biol Chem 278:42524~42531
Chen L / 2006 / Roles of cortactin, an actin polymerization mediator, in cell endocytosis / Acta Biochim Biophys Sin 38:95~103
Abraham S / 2001 /
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