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Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한구강생물학회 International Journal of Oral Biology International Journal of Oral Biology 제44권 제1호 KCI Accredited Journals
- 발행연도
- 2019.1
- 수록면
- 20 - 26 (7page)
이용수
Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression
초록· 키워드
오류제보하기
Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis , a major periodontopathic pathogen, plays a critical role in the pathogenesis of atherosclerosis. In the present study, we demonstrated that P. gingivalis lipopolysaccharide (LPS) increases the mRNA and protein expression of matrix metalloproteinase-9 (MMP-9) in rat vascular smooth muscle cells. We showed that the MMP-9 expression induced by P. gingivalis LPS is mediated by the activation of signal transducer and activator of transcription 3 (STAT3) in vascular smooth muscle cells. Furthermore, the inhibition of STAT3 activity reduced P. gingivalis LPS-induced migration of vascular smooth muscle cells. Overall, our findings indicate that P. gingivalis LPS stimulates the migration of vascular smooth muscle cells via STAT3-mediated MMP-9 expression.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
R. Hegde / 2019 / Effects of periodontal disease on systemic health / Disease-a-Month 65(6):185~192
C.M. Nguyen / 2015 / Periodontal associations in cardiovascular diseases: The latest evidence and understanding / Journal of Oral Biology and Craniofacial Research 5(3):203~206
Karim El Kholy / 2015 / Oral infections and cardiovascular disease / Trends in Endocrinology & Metabolism 26(6):315~321
F.C. Gibson / 2016 / Innate immune signaling and Porphyromonas gingivalisaccelerated atherosclerosis / Journal of Dental Research 85(2):106~121
V.I. Haraszthy / 2000 / Identification of Periodontal Pathogens in Atheromatous Plaques / Journal of Periodontology 71(10):1554~1560
C.M. Nguyen / 2015 / Periodontal associations in cardiovascular diseases: The latest evidence and understanding / Journal of Oral Biology and Craniofacial Research 5(3):203~206
Karim El Kholy / 2015 / Oral infections and cardiovascular disease / Trends in Endocrinology & Metabolism 26(6):315~321
F.C. Gibson / 2016 / Innate immune signaling and Porphyromonas gingivalisaccelerated atherosclerosis / Journal of Dental Research 85(2):106~121
V.I. Haraszthy / 2000 / Identification of Periodontal Pathogens in Atheromatous Plaques / Journal of Periodontology 71(10):1554~1560
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