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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 17 - 23 (7page)
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Chronic/cyclic neutropenia, leukocyte adhesion deficiency syndrome, Papillon-Lefèvre syndrome, and Chédiak-Higashi syndrome are associated with severe periodontitis, suggesting the importance of neutrophils in the maintenance of periodontal health. Various Toll-like receptor (TLR) ligands are known to stimulate neutrophil function, including FcR-mediated phagocytosis. In the present study, the effect of TLR2 activation on the non-opsonic phagocytosis of oral bacteria and concomitant production of reactive oxygen species (ROS) by human neutrophils was evaluated. Neutrophils isolated from peripheral blood were incubated with Streptococcus sanguinis or Porphyromonas gingivalis in the presence of various concentrations of Pam3CSK4, a synthetic TLR2 ligand, and analyzed for phagocytosis and ROS production by flow cytometry and chemiluminescence, respectively. Pam3CSK4 significantly increased the phagocytosis of both bacterial species in a dose-dependent manner. However, the enhancing effect was greater for S. sanguinis than for P. gingivalis. Pam3CSK4 alone induced ROS production in neutrophils and also increased concomitant ROS production induced by bacteria. Interestingly, incubation with P. gingivalis and Pam3CSK4 decreased the amounts of ROS, as compared to Pam3CSK4 alone, indicating the possibility that P. gingivalis survives within neutrophils. However, neutrophils efficiently killed phagocytosed bacteria of both species despite the absence of Pam3CSK4. Although P. gingivalis is poorly phagocytosed even by the TLR2-activated neutrophils, TLR2 activation of neutrophils may help to reduce the colonization of P. gingivalis by efficiently eliminating S. sanguinis , an early colonizer, in subgingival biofilm.
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참고문헌 (29)
참고문헌 신청
George Hajishengallis / 2014 / Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response / Trends in Immunology 35(1):3~11
Bruce A. Dye / 2012 / Global periodontal disease epidemiology / Periodontology 2000 58(1):10~25
J. A. Aas / 2005 / Defining the Normal Bacterial Flora of the Oral Cavity / Journal of Clinical Microbiology 43(11):5721~5732
Socransky SS / 1998 / Microbial complexes in subgingival plaque / J Clin Periodontol 25:134~144
Zhimin Feng / 2006 / Role of bacteria in health and disease of periodontal tissues / Periodontology 2000 40(1):50~76
Bruce A. Dye / 2012 / Global periodontal disease epidemiology / Periodontology 2000 58(1):10~25
J. A. Aas / 2005 / Defining the Normal Bacterial Flora of the Oral Cavity / Journal of Clinical Microbiology 43(11):5721~5732
Socransky SS / 1998 / Microbial complexes in subgingival plaque / J Clin Periodontol 25:134~144
Zhimin Feng / 2006 / Role of bacteria in health and disease of periodontal tissues / Periodontology 2000 40(1):50~76
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