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자료유형
학술저널
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저널정보
대한구강생물학회 International Journal of Oral Biology International Journal of Oral Biology 제32권 제4호
발행연도
2007.1
수록면
143 - 151 (9page)

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This study was conducted to investigate the preventing effects of OPB (Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max extracts) and combined OPB/ Calcium therapy on bone loss in ovariectomized rats. Sixty Sprague Dawley rats of 12-week-old were divided into eight groups: OVX (ovariectomized), OPBL (OPB 50 mg/kg), OPBM (OPB100 mg/kg), OPBH (OPB 200 mg/kg), OPBL/ CAL(OPBL+CAL), OPBM/CAL (OPBM+CAL), OPBH/ CAL (OPBH+CAL) and CAL (Calcium citrate 88.33 mg/kg +1α, 25-dihydroxy-vitamin D3 33.33 IU/kg). Bone mineral density (BMD), bone mineral content (BMC), bone strength indices and cortical thickness were analyzed by peripheral quantitative computerized tomography (pQCT). pQCT scanning showed that OVX induced a significant decrease in trabecular bone mineral density and bone mineral content in the proximal tibia (-36.4±2.4%, -21.8±12.7%). These decreases were significantly prevented by the administration of OPBM and OPBM/CAL. Cortical BMD and BMC of tibia were slightly enhanced by OPB and OPB/ CAL. However there was no significant difference between OVX and OPB, OPB/CAL treated group. Bone strength indices and cortical thickness were not significantly different. Our results suggest that OPB and combined OPB/Calcium therapy are effective in preventing the development of bone loss induced by ovariectomy in rats.

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