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논문 기본 정보

자료유형
학술저널
저자정보
So-Young Choi (충북대학교) Dongsun Park (충북대학교) Goeun Yang (충북대학교) Sun Hee Lee (충북대학교) Dae Kwon Bae (충북대학교) Seock-Yeon Hwang (대전대학교) Paul K Lee (NTS Research & Inc.) Yun-Bae Kim (충북대학교) Ill-Hwa Kim (충북대학교) Hyun-Gu Kang (충북대학교)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.27 No.4
발행연도
2011.12
수록면
301 - 307 (7page)

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초록· 키워드

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This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17β-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17β-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.

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Materials and Methods
Results
Discussion
Acknowledgment
References

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UCI(KEPA) : I410-ECN-0101-2013-510-001228126