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논문 기본 정보

자료유형
학술저널
저자정보
Seul Ki Lim (World Institute of Kimchi) Dong Il Kim (Chonnam National University) Min Jung Park (Chonnam National University) Joo Hee Choi (Chonnam National University) Young Kuk Kim (Dasan Institute of Life & Science) An Chul Lee (Dasan Institute of Life & Science) Mi Young Choi (Dasan Institute of Life & Science) Soo Hyun Park (Chonnam National University)
저널정보
대한의생명과학회 대한의생명과학회지 대한의생명과학회지 제20권 제3호
발행연도
2014.9
수록면
156 - 161 (6page)

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It has been reported that safflower seeds have preventive effects against osteoporosis. Recently, safflower buds (SB) were found to have more useful functional ingredients than safflower seeds. In the current study, we evaluated the anti-osteoporosis effects of SB diet in ovariectomized (OVX) rats. The rats were divided into five groups; sham operated group, OVX alone group, OVX plus 17β-estradiol (E2 10 μg/kg, i.p.) and OVX plus SB diet feeding group (0.3% or 1%). Feeding of SB diet (0.3% or 1%) to OVX rats markedly increased bone mineral density (BMD) of femurs, compared to the OVX group. The OVX rats exhibited a marked increase in trabecular separation (Tb.Sp) and this change was inhibited by the feeding of SB diet, similar to that seen with OVX+E2 group. Moreover, feeding of SB diet to OVX rats decreased the markers of bone turnover, including osteocalcin and alkaline phosphatase (ALP). These results suggest that SB extract has a bone sparing effect in OVX-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover. Therefore, SB may be useful for preserving bone mass and structure in estrogen deficient women with a potential role in reducing postmenopausal osteoporosis.

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES

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