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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 51 - 58 (8page)
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초록· 키워드
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A mutation of UNCL, an inner nuclear membrane RNAbinding
protein, has been found to eliminate mechanotransduction
in Drosophila. UNCL is expressed in human
periodontal tissue including in periodontal ligament (PDL)
fibroblasts. However, it is unclear how a mechanical
stimulus is translated into cellular responses in PDL
fibroblasts. The aim of this study was to evaluate the effect
of UNCl on mechanical stress related genes in PDL
fibroblasts in response to mechanical stress. The mRNA of
TGF-β, COX-2, and MMP-2 was up-regulated after UNCL
inactivation in PDL fibroblasts under the compression
force. Under the tensile force, inactivation of UNCL
decreased the expression of Biglycan, RANKL, MMP-2,
and TIMP-2 mRNAs while it increased the expression of
TIMP-1. p38-MAPK was expressed in PDL fibroblasts
under compression forces whereas phospho-ERK1/2, p65-
NFkB, and c-fos were expressed under tension forces. The
expression and phosphorylation of the mechanical stress
related genes, kinases, and transcription factors were
changed according to the types of stress. Furthermore, most
of them were regulated by the inactivation of UNCL. This
suggests that UNCL is involved in the regulation of
mechanical stress related genes through the signaling
pathway in PDL fibroblasts.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Bolcato-Bellemin, A. L. / 2000 / Expression of mRNAs encoding for alpha and beta integrin subunits, MMPs, and TIMPs in stretched human periodontal ligament and gingival fibro
Carnes, D. L. / 1997 / Cells with osteoblastic phenotypes can be explanted from human gingival and periodontal ligament / Journal of Periodontology 68 : 701 ~ 70
Chantalat, S. / 2003 / A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p / molecular biology of the cell 14 : 2357 ~ 2371
Evanko, S. P / 1993 / Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro / Archives of Biochemistry and Biophysics 307 : 153 ~
Fitzgerald, J. / 2000 / UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein / Brain Research 877 : 110 ~ 123
Carnes, D. L. / 1997 / Cells with osteoblastic phenotypes can be explanted from human gingival and periodontal ligament / Journal of Periodontology 68 : 701 ~ 70
Chantalat, S. / 2003 / A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p / molecular biology of the cell 14 : 2357 ~ 2371
Evanko, S. P / 1993 / Proteoglycan synthesis in fetal tendon is differentially regulated by cyclic compression in vitro / Archives of Biochemistry and Biophysics 307 : 153 ~
Fitzgerald, J. / 2000 / UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein / Brain Research 877 : 110 ~ 123
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