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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 137 - 142 (6page)
이용수
초록· 키워드
오류제보하기
Whole-body γ-irradiation(WBI), which produces an oxidative
stress, is reported to attenuate the acute antinociceptive
action of morphine (a μ-opioid receptor agonist), but not
DPLPE (a δ-opioid receptor agonist), in mice. Recently, we
also reported that antinociceptive effect of morphine, but
not β-endorphin (a novel ε-opioid receptor agonist), was
attenuated by oxidative stress. These findings prompted us
to investigate the effect of WBI on the antinociception of
morphine and β-endorphin in mice. Mice were exposed to
WBI (5 Gy) from a
60
Co gamma-source and tested 2 hours
later for antinociception produced by intracerebroventricular
administration of morphine or β-endorphin using the
hot water tail-immersion and the writhing tests. WBI
significantly attenuated the antinociception produced by
morphine only in the hot water tail-immersion test, whereas
the antinociception of β-endorphin was significantly potentiated
by WBI in both tests. These results demonstrate a
differential sensitivity of μ- and ε-opioid receptors to WBI,
and support the hypothesis that morphine and β-endorphin
administered supraspinally produce antinociception by
different neuronal mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ben-Bassat J / 1959 / Analgesimetry and ranking of analgesic drugs by the receptacle method / Arch Int Pharmacodyn Ther 122 : 434 ~ 447
Chung KM / 1997 / Effects of morphine and β-endorphin administered intracerebroventricularly on the release of neurotransmitters in medullary dorsal horn / J Dent Coll. S.N.
Chung KM / 2001 / Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphininduced antinociception in the mouse formalin test / Neuro
Chung KM / 2003 / Differential involvement of glutathione in morphine and β-endorphin induced antinociception in male ICR mice / Int J Oral Biol 28 (2) : 33 ~ 37
Gwi Y. Yang / 2008 / Compression of The Trigeminal Ganglion Enhances Nociceptive Behavior Produced by Formalin in The Orofacial Area of Rats / International Journal of Oral
Chung KM / 1997 / Effects of morphine and β-endorphin administered intracerebroventricularly on the release of neurotransmitters in medullary dorsal horn / J Dent Coll. S.N.
Chung KM / 2001 / Pretreatment with cholera or pertussis toxin differentially modulates morphine- and beta-endorphininduced antinociception in the mouse formalin test / Neuro
Chung KM / 2003 / Differential involvement of glutathione in morphine and β-endorphin induced antinociception in male ICR mice / Int J Oral Biol 28 (2) : 33 ~ 37
Gwi Y. Yang / 2008 / Compression of The Trigeminal Ganglion Enhances Nociceptive Behavior Produced by Formalin in The Orofacial Area of Rats / International Journal of Oral
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