지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 236 - 241 (6page)
이용수
초록· 키워드
오류제보하기
Background:Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis, evidences suggesting endogenous opioid peptide link in spinal antinociception of COX inhibitor have been reported. We investigated the roles of opioid receptor subtypes in the spinal antinociception of selective COX-2 inhibitor.
Methods:To examine the antinociception of a selective COX-2 inhibitor, DUP-697 was delivered through an intrathecal catheter, 10 minutes before the formalin test in male Sprague-Dawley rats. Then, the effect of intrathecal pretreatment with CTOP, naltrindole and GNTI, which are m, d and k opioid receptor antagonist, respectively, on the analgesia induced by DUP-697 was assessed.
Results:Intrathecal DUP-697 reduced the flinching response evoked by formalin injection during phase 1 and 2. Naltrindole and GNTI attenuated the antinociceptive effect of intrathecal DUP-697 during both phases of the formalin test. CTOP reversed the antinociception of DUP-697 during phase 2, but not during phase 1.
Conclusions:Intrathecal DUP-697, a selective COX-2 inhibitor, effectively relieved inflammatory pain in rats. The d and k opioid receptors are involved in the activity of COX-2 inhibitor on the facilitated state as well as acute pain at the spinal level, whereas the m opioid receptor is related only to facilitated pain. (Korean J Pain 2010; 23: 236-241)
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Domer F / 1990 / Characterization of the analgesic activity of ketorolac in mice / Eur J Pharmacol 177 : 127 ~ 135
Franca DS / 2006 / Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo- oxygenase 2 in rat paws treated with carrageenan / Neuropharmacology 5
Herrero JF / 1991 / The effects of sham and full spinalization on the systemic potency of mu- and kappa- opioids on spinal nociceptive reflexes in rats / Br J Pharmacol 104
Herrero JF / 1996 / Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID / Br J Pharmacol 118 : 968 ~ 972
Iadarola MJ / 1988 / Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization / Brain Res 455 : 205 ~ 2
Franca DS / 2006 / Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo- oxygenase 2 in rat paws treated with carrageenan / Neuropharmacology 5
Herrero JF / 1991 / The effects of sham and full spinalization on the systemic potency of mu- and kappa- opioids on spinal nociceptive reflexes in rats / Br J Pharmacol 104
Herrero JF / 1996 / Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID / Br J Pharmacol 118 : 968 ~ 972
Iadarola MJ / 1988 / Differential activation of spinal cord dynorphin and enkephalin neurons during hyperalgesia: evidence using cDNA hybridization / Brain Res 455 : 205 ~ 2
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