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논문 기본 정보

자료유형
학술저널
저자정보
Han Ki-Jung (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Choi Seong-Soo (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Lee Jin-Young (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Lee Han-Kyu (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Shim Eon-Jeong (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Kwon Min Soo (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Seo Young-Jun (Department of Pharmacology and Institute of Natural Medicine, Hallym University) Suh Hong-Won (Department of Pharmacology and Institute of Natural Medicine, Hallym University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제28권 제2호
발행연도
2005.1
수록면
209 - 215 (7page)

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초록· 키워드

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The antinociceptive effect of nicotine administered intracereboventricularly (i.c.v.) or intrathecally (i.t) in several pain models was examined in the present study. We found that i.t. treatment with nicotine (from 5 to 20 g) dose-dependently blocked pain behavior revealed during the second phase, but not during the first phase in the formalin test. In addition, i.c.v. treatment with nicotine (from 0.1 to $10\;{\mu}g$) dose-dependently attenuated pain behavior revealed during both the first and second phases. In addition to the formalin test, nicotine administered i.c.v. or i.t. attenuated acetic acid-induced writhing response. Furthermore, i.c.v. or i.t. administration of nicotine did not cause licking, scratching and biting responses induced by substance P, glutamate, TNF-${\alpha}$(100 pg), IL-$1{\beta}$(100 pg) and INF-${\gamma}$ (100 pg) injectied i.t. The antinociception induced by supraspinally-administered nicotine appears to be more effective than that resulting from spinally administered nicotine. Our results suggest that nicotine administration induces antinociception by acting on the central nervous system and has differing antinociceptive profiles according to the various pain models.

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