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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 131 - 135 (5page)
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The sublingual locus has recently received great attention
as a delivery site for various immunotherapies, including
those that induce allergen-specific tolerance, and for vaccines
that generate protective immunity. To further understand
the immune functions of the human sublingual mucosa, we
characterized the distribution of various immunocytes
therein by immunohistochemistry. We identified professional
antigen presenting cells (APCs), including Langerhans cells
(LCs) and macrophages. CD1a+ and langerin+ LCs were
further found to be distributed in the basal and supra-basal
layers of the epithelium, and macrophages were identified in
the lamina propria. HLA-DR+ cells were observed in both
the epithelium and the lamina propria, which mirrors the
tissue distribution of LCs and macrophages within these
tissues. CD3+, CD4+, and CD8+ T cells were found to be
distributed along the basal layer of the epithelium and also
in the lamina propria. Although B cells, plasma cells, and
Foxp3+ regulatory T cells (Tregs) were only occasionally
observed in the human sublingual mucosa in the absence of
inflammation, they did show enrichment at inflammatory
sites. Hence, we have further elucidated the immune cell
component distribution in human sublingual mucosa.
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등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
Allam JP / 2008 / Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy / Allergy 63 :
Holmgren J / 2005 / Mucosal immunity and vaccines / Nat Med 11 : S45 ~ S53
Ito H / 1998 / Three-dimensional appearance of Langerhans cells in human gingival epithelium as revealed by confocal laser scanning microscopy / Arch Oral Biol 43 : 741 ~ 744
Moingeon P / 2006 / Van Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotherapy / Allergy 61 : 151 ~ 165
Novak N / 1989 / The immune privilege of the oral mucosa. Trends Mol Med. 2008;14:191-8. Sanderson RD, Lalor P, Bernfield M. B lymphocytes express and lose syndecan at specif
Holmgren J / 2005 / Mucosal immunity and vaccines / Nat Med 11 : S45 ~ S53
Ito H / 1998 / Three-dimensional appearance of Langerhans cells in human gingival epithelium as revealed by confocal laser scanning microscopy / Arch Oral Biol 43 : 741 ~ 744
Moingeon P / 2006 / Van Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotherapy / Allergy 61 : 151 ~ 165
Novak N / 1989 / The immune privilege of the oral mucosa. Trends Mol Med. 2008;14:191-8. Sanderson RD, Lalor P, Bernfield M. B lymphocytes express and lose syndecan at specif
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